Document Detail

Changes in endochondral bone elongation rates during pregnancy and lactation in rats.
MedLine Citation:
PMID:  6442205     Owner:  NLM     Status:  MEDLINE    
The rates of endochondral bone elongation during pregnancy and lactation in rats have been studied. The rate of growth at the distal femoral epiphyseal growth plate was measured using fluorescent bone markers. Endochondral growth rates were substantially increased in pregnant animals when compared with age-matched, nonmated controls. There were also increases in growth plate thickness, hypertrophic cell lacunar height, and the calculated rate of cell production during pregnancy. At parturition, this growth trend was reversed and during lactation there were significant decreases in endochondral growth rates. There were also corresponding decreases in growth plate thickness, hypertrophic cell lacunar height, and the calculated rate of cartilage cell production. These results indicate that significant changes occur in maternal endochondral growth rates during the reproductive cycle in rats.
E H Redd; S C Miller; W S Jee
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Calcified tissue international     Volume:  36     ISSN:  0171-967X     ISO Abbreviation:  Calcif. Tissue Int.     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-05-10     Completed Date:  1985-05-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7905481     Medline TA:  Calcif Tissue Int     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  697-701     Citation Subset:  IM; S    
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MeSH Terms
Bone Development*
Femur / growth & development
Growth Plate / anatomy & histology*
Rats, Inbred Strains
Tibia / growth & development
Grant Support

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