Document Detail


Changes in electrical activity of myometrium during intrauterine distribution of rat blastocysts and after prazosin administration.
MedLine Citation:
PMID:  2754655     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the early pregnant rat, electrical activity of the myometrium consisted of regular bursts of spike potential, which appeared well propagated on Day 2 of pregnancy. During Day 3, there was a gradual disappearance of propagated activity. Concomitantly, there was a 7-fold increase (P less than 0.001) of uterine progesterone concentrations. At this stage, mean duration of bursts was 15.2 +/- 0.9 sec and intervals of complete quiescence between bursts were 84.2 +/- 7.0 sec. At 10:00 h on Day 4, there were peaks in the uterine concentrations of oestradiol and progesterone, +36% and +654%, respectively, compared with values on Day 2 (P less than 0.05). Between 10:00 and 20:00 h on Day 4, EMG activity exhibited a rapid and transient rise: bursts were of longer duration at the utero-tubal end of the horn (+60%, P less than 0.05) with an increased amplitude of spike potentials (+67% and +90% respectively at the tubal and cervical ends of the uterus, P less than 0.05). The administration of prazosin depressed EMG activity reversibly in a dose-dependent manner with maximal inhibition at about 2-3 h later. It is concluded that the changes observed during EMG recordings are relevant to the intrauterine distribution of blastocysts and related to changes in the steroidal environment and/or to catecholamine effects via alpha 1-adrenoceptors.
Authors:
C Legrand; A Banuelos-Nevarez; J P Maltier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of reproduction and fertility     Volume:  86     ISSN:  0022-4251     ISO Abbreviation:  J. Reprod. Fertil.     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-08-31     Completed Date:  1989-08-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376367     Medline TA:  J Reprod Fertil     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  39-49     Citation Subset:  IM    
Affiliation:
Université Pierre et Marie Curie, C.N.R.S. URA 4, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blastocyst / physiology*
Electrophysiology
Estradiol / analysis
Female
Myometrium / drug effects,  physiology*
Prazosin / pharmacology*
Pregnancy
Pregnancy, Animal / physiology*
Progesterone / analysis
Rats
Rats, Inbred Strains
Uterus / analysis,  anatomy & histology
Chemical
Reg. No./Substance:
19216-56-9/Prazosin; 50-28-2/Estradiol; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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