| Changes in electrical activity of myometrium during intrauterine distribution of rat blastocysts and after prazosin administration. | |
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MedLine Citation:
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PMID: 2754655 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the early pregnant rat, electrical activity of the myometrium consisted of regular bursts of spike potential, which appeared well propagated on Day 2 of pregnancy. During Day 3, there was a gradual disappearance of propagated activity. Concomitantly, there was a 7-fold increase (P less than 0.001) of uterine progesterone concentrations. At this stage, mean duration of bursts was 15.2 +/- 0.9 sec and intervals of complete quiescence between bursts were 84.2 +/- 7.0 sec. At 10:00 h on Day 4, there were peaks in the uterine concentrations of oestradiol and progesterone, +36% and +654%, respectively, compared with values on Day 2 (P less than 0.05). Between 10:00 and 20:00 h on Day 4, EMG activity exhibited a rapid and transient rise: bursts were of longer duration at the utero-tubal end of the horn (+60%, P less than 0.05) with an increased amplitude of spike potentials (+67% and +90% respectively at the tubal and cervical ends of the uterus, P less than 0.05). The administration of prazosin depressed EMG activity reversibly in a dose-dependent manner with maximal inhibition at about 2-3 h later. It is concluded that the changes observed during EMG recordings are relevant to the intrauterine distribution of blastocysts and related to changes in the steroidal environment and/or to catecholamine effects via alpha 1-adrenoceptors. |
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Authors:
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C Legrand; A Banuelos-Nevarez; J P Maltier |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of reproduction and fertility Volume: 86 ISSN: 0022-4251 ISO Abbreviation: J. Reprod. Fertil. Publication Date: 1989 May |
Date Detail:
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Created Date: 1989-08-31 Completed Date: 1989-08-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376367 Medline TA: J Reprod Fertil Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 39-49 Citation Subset: IM |
Affiliation:
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Université Pierre et Marie Curie, C.N.R.S. URA 4, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blastocyst / physiology* Electrophysiology Estradiol / analysis Female Myometrium / drug effects, physiology* Prazosin / pharmacology* Pregnancy Pregnancy, Animal / physiology* Progesterone / analysis Rats Rats, Inbred Strains Uterus / analysis, anatomy & histology |
| Chemical | |
Reg. No./Substance:
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19216-56-9/Prazosin; 50-28-2/Estradiol; 57-83-0/Progesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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