| Changes in ect2 localization couple actomyosin-dependent cell shape changes to mitotic progression. | |
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MedLine Citation:
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PMID: 22898780 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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As they enter mitosis, animal cells undergo profound actin-dependent changes in shape to become round. Here we identify the Cdk1 substrate, Ect2, as a central regulator of mitotic rounding, thus uncovering a link between the cell-cycle machinery that drives mitotic entry and its accompanying actin remodeling. Ect2 is a RhoGEF that plays a well-established role in formation of the actomyosin contractile ring at mitotic exit, through the local activation of RhoA. We find that Ect2 first becomes active in prophase, when it is exported from the nucleus into the cytoplasm, activating RhoA to induce the formation of a mechanically stiff and rounded metaphase cortex. Then, at anaphase, binding to RacGAP1 at the spindle midzone repositions Ect2 to induce local actomyosin ring formation. Ect2 localization therefore defines the stage-specific changes in actin cortex organization critical for accurate cell division. |
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Authors:
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Helen K Matthews; Ulysse Delabre; Jennifer L Rohn; Jochen Guck; Patricia Kunda; Buzz Baum |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Developmental cell Volume: 23 ISSN: 1878-1551 ISO Abbreviation: Dev. Cell Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-08-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101120028 Medline TA: Dev Cell Country: United States |
Other Details:
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Languages: eng Pagination: 371-83 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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MRC Laboratory for Molecular Cell Biology, University College London, Gower St., London WC1E 6BT, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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