| Changes in echocardiographic measures of systolic and diastolic function in children 1 year after hematopoietic SCT. | |
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MedLine Citation:
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PMID: 21278798 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hematopoietic SCT (HSCT) is a life-saving therapy in children, but has been associated with heart failure. Little is known about subclinical changes in cardiac function. We examined changes in systolic and diastolic function from pre- to 1-year post HSCT by echocardiography. All patients (n=74, 61% men, median age 9.1 years, mean left-ventricular (LV) ejection fraction 61.3±4.9%) who underwent HSCT at Children's Hospital Boston between 2005 and 2008, were <21 years at time of HSCT, and had routine pre- and 1-year post echocardiograms were included. Systolic function parameters, including LV ejection fraction, rate-corrected velocity of fiber shortening (Vcfc) and stress-velocity index and diastolic parameters, including tissue Doppler imaging (TDI)-derived velocities, and left-ventricular flow propagation, were compared before and after transplant. At 1-year post HSCT, systolic function, as measured by Vcfc (1.10±0.15 vs 1.04±0.12 circ/s; P=0.03) and stress-velocity index (z-score 0.40±1.4 vs -0.20±1.1; P=0.02), had worsened; diastolic function parameters, including mitral E' velocity (16.6±3.9 vs 15.0±3.4 cm/s; P=0.01) and tricuspid E' velocity (14.3±3.6 vs 12.4±2.8 cm/s; P=0.002) had also decreased. At 1-year post HSCT, children have subclinical declines in systolic and diastolic function. These small changes might become clinically important over time. Serial non-invasive assessment of cardiac function should be considered in all children following HSCT. |
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Authors:
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K P Daly; S D Colan; E D Blume; R Margossian; K Gauvreau; C Duncan; L E Lehmann; M H Chen |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-01-31 |
Journal Detail:
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Title: Bone marrow transplantation Volume: 46 ISSN: 1476-5365 ISO Abbreviation: Bone Marrow Transplant. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-07 Completed Date: 2012-04-03 Revised Date: 2012-09-18 |
Medline Journal Info:
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Nlm Unique ID: 8702459 Medline TA: Bone Marrow Transplant Country: England |
Other Details:
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Languages: eng Pagination: 1532-9 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Children's Hospital Boston, Boston, MA 02115, USA. kevin.daly@childrens.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Child Child, Preschool Echocardiography, Doppler* Follow-Up Studies Hematopoietic Stem Cell Transplantation* Humans Male Retrospective Studies Stroke Volume* Transplantation, Homologous Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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T32 HL007572-26/HL/NHLBI NIH HHS; T32 HL07572/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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