Document Detail

Changes in dopamine receptor sensitivity in humans after heavy alcohol intake.
MedLine Citation:
PMID:  2862656     Owner:  NLM     Status:  MEDLINE    
Dopamine (DA) sensitivity, assessed through maximal growth hormone (GH) response to stimulation by apomorphine (APO) (0.18-0.24 mg iv) was studied in 16 chronic alcoholics newly admitted after a period of heavy alcohol intake. Repeated hormonal tests were thereafter performed during a 2-month period under strictly controlled conditions to avoid relapse into alcohol consumption. Eight healthy volunteers with alcohol consumption slightly less than that of the general population were used as controls. It was found that DA sensitivity in the early abstinence phase was higher than later in the 2-month recovery period but not significantly different from control values. The relatively higher DA sensitivity in the early abstinence phase might be responsible for a lower threshold for psychotic symptoms and neuroleptic-induced extrapyramidal side effects. The results of this study give further evidence of a prolonged recovery phase after heavy alcohol intake.
J Balldin; C Alling; C G Gottfries; G Lindstedt; G Långström
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychopharmacology     Volume:  86     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1985  
Date Detail:
Created Date:  1985-09-25     Completed Date:  1985-09-25     Revised Date:  2009-10-02    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  142-6     Citation Subset:  IM    
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MeSH Terms
Alcoholism / drug therapy,  physiopathology*
Anti-Anxiety Agents / therapeutic use
Anticonvulsants / therapeutic use
Apomorphine / diagnostic use
Chlormethiazole / analogs & derivatives,  therapeutic use
Ethanol / adverse effects
Growth Hormone / secretion*
Middle Aged
Pituitary Gland, Anterior / physiopathology*
Receptors, Dopamine / physiology*
Substance Withdrawal Syndrome / physiopathology
Reg. No./Substance:
0/Anti-Anxiety Agents; 0/Anticonvulsants; 0/Receptors, Dopamine; 12794-10-4/Benzodiazepines; 1867-58-9/clomethiazole edisylate; 533-45-9/Chlormethiazole; 58-00-4/Apomorphine; 64-17-5/Ethanol; 9002-72-6/Growth Hormone

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