Document Detail

Changes in donor corneal lenticule thickness after Descemet's stripping automated endothelial keratoplasty (DSAEK) with organ-cultured corneas.
MedLine Citation:
PMID:  19244269     Owner:  NLM     Status:  MEDLINE    
AIMS: The aim of the study was to quantify changes in donor and host corneal tissue after Descemet's stripping automated endothelial keratoplasty (DSAEK) using organ-cultured corneas and to correlate these findings with the visual acuity during intermediate-term follow-up. METHODS: Fifteen eyes of 15 consecutive patients, with Fuchs' endothelial dystrophy treated with DSAEK using organ-cultured corneas, underwent ophthalmological examination, including slit lamp-adapted optical coherence tomography, at 1, 3 and 7 days, and 4 weeks, 8 weeks and 6 months after the surgery. RESULTS: The mean best spectacle-corrected visual acuity (BSCVA) improved from 20/100 pre-operatively to 20/40 at 6-months post-operatively (p<0.0001). A continuous decrease of thickness of the grafted lenticule was observed during the follow-up (mean thickness immediately after surgery 191(SD 56) mum, compared with 100 (SD 38) mum 6 months after surgery, p<0.001). The central corneal thickness decreased from 1057 (SD 86) mum at the first post-operative day to 661 (SD 74) mum after 6 months. Both central corneal thickness and the thickness of the posterior donor lamella correlated with the 6-month BSCVA (Pearson correlations -0.745 and -0.589, respectively, p<0.05). CONCLUSIONS: Organ-cultured corneas can be used successfully for DSAEK. The thickness of the grafted corneal lenticule correlated with the BSCVA 6 months after the surgery. It decreased continuously during the follow-up period.
P Pogorelov; C Cursiefen; B O Bachmann; F E Kruse
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Publication Detail:
Type:  Journal Article     Date:  2009-02-24
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  93     ISSN:  1468-2079     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-27     Completed Date:  2009-06-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  825-9     Citation Subset:  IM    
Department of Opthalmology, University of Erlangen-Nuremberg, Schwabachanlage 6, D-91054 Erlangen, Germany.
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MeSH Terms
Aged, 80 and over
Cornea / pathology*
Corneal Transplantation / methods*
Descemet Membrane / surgery*
Endothelium, Corneal / surgery
Follow-Up Studies
Fuchs' Endothelial Dystrophy / surgery*
Graft Survival
Organ Culture Techniques
Tomography, Optical Coherence
Visual Acuity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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