Document Detail

Changes in cranial CSF volume during hypercapnia and hypocapnia.
MedLine Citation:
PMID:  2495339     Owner:  NLM     Status:  MEDLINE    
Magnetic resonance imaging was used to measure the effect of inhalation of 7% CO2 and hyperventilation with 60% O2 on human cranial cerebrospinal fluid volume. During CO2 inhalation there was a reduction in the cranial CSF volume ranging from 0.7-23.7 ml (mean 9.36 ml). The degree of reduction in cranial CSF volume was independent of the individual subject's increase in end-expiratory pCO2 or mean arterial blood pressure, in response to hypercapnia. During hyperventilation with high concentration oxygen the cranial CSF volume increased in all subjects (range 0.7-26.7 ml, mean 12.7 ml). The mean changes in cranial CSF volume, induced by hypercapnia and hypocapnia, were very similar to the expected reciprocal changes in cerebral blood volume.
R Grant; B Condon; J Patterson; D J Wyper; M D Hadley; G M Teasdale
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  52     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-05-15     Completed Date:  1989-05-15     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  218-22     Citation Subset:  IM; S    
University Department of Neurosurgery, Glasgow, Scotland, UK.
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MeSH Terms
Carbon Dioxide / blood*
Cerebrospinal Fluid / physiology*
Hypercapnia / physiopathology*
Intracranial Pressure*
Magnetic Resonance Imaging
Oxygen / blood
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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