Document Detail


Changes in coronary and collateral flows and adequacy of perfusion in the dog following one and three months of circumflex occlusion.
MedLine Citation:
PMID:  975454     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated changes in circumflex, left anterior descending (LAD), and right coronary artery flows as well as changes in collateral flows to these vessels after long-term circumflex occlusion. Coronary and collateral flows of each vessel were determined simultaneously in an isolated heart preparation in which the vasculature was maximally dilated with dipyridamole. The resistances as related to total heart weight of the circumflex, LAD, and right coronary arteries of 16 control dogs were found to be 0.59 +/- 0.06, 0.93 +/- 0.09, and 2.37 +/- 0.17 (mean +/- SEM) mm Hg/[(ml/min)/100 g], respectively. Total minimal coronary resistance was 0.21 +/- 0.01. In 10 dogs subjected to occlusion for 1 month no significant change in circumflex coronary resistance was observed, but the resistance of the unimpaired vessels decreased significantly. The resistances of the LAD and right coronary arteries were 0.66 +/-0.04 and 1.72 +/- 0.13, respectively. Both values were considerably less (P less than 0.01) than control. In nine dogs subjected to occlusion for 3 months the resistance of the unimpaired LAD and right arteries, as well as the circumflex coronary resitance, were not significantly different from control. We also found that retrograde flows for all vessels increased 7-fold after 1 month and 10.5-fold (relative to control) after 3 months of occlusion. From these data we conclude that vascular adaptations, which occurred in response to an ischemic stimulus, are responsible for the long-term regulation of the metabolic needs of the myocardium.
Authors:
K W Scheel; T A Galindez; B Cook; R J Rodriguez; L A Ingram
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation research     Volume:  39     ISSN:  0009-7330     ISO Abbreviation:  Circ. Res.     Publication Date:  1976 Nov 
Date Detail:
Created Date:  1976-12-30     Completed Date:  1976-12-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  654-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arterial Occlusive Diseases / physiopathology*
Blood Flow Velocity
Collateral Circulation*
Coronary Circulation*
Coronary Disease / physiopathology*
Coronary Vessels / physiopathology
Dogs
Male
Perfusion
Time Factors
Vascular Resistance

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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