Document Detail

Changes in the content of GFAP in the rat brain during pregnancy and the beginning of lactation.
MedLine Citation:
PMID:  20732387     Owner:  NLM     Status:  In-Process    
Several changes in brain function, including learning and memory, have been reported during pregnancy but the molecular mechanisms involved in these changes are unknown. Due to the fundamental role of glial cells in brain activity, we analyzed the content of glial fibrillary acidic protein (GFAP) in the hippocampus, frontal cortex, preoptic area, hypothalamus and cerebellum of the rat on days 2, 14, 18, and 21 of pregnancy and on day 2 of lactation by Western blot. A differential expression pattern of GFAP was found in the brain during pregnancy and the beginning of lactation. GFAP content was increased in the hippocampus throughout pregnancy, whereas a decrease was observed in cerebellum. GFAP content was increased in the frontal cortex and hypothalamus on days 14 and 18, respectively, with a decrease in the following days of pregnancy in both regions. In preoptic area a decrease in GFAP content was observed on day 14 with an increase on days 18 and 21. In the frontal cortex and cerebellum, GFAP content was increased on day 2 of lactation, while it was maintained as on day 21 of pregnancy in the other regions. Our data suggest a differential expression pattern of GFAP in the rat brain during pregnancy and the beginning of lactation that should be associated with changes in brain function during these reproductive stages.
Porfirio Gómora-Arrati; Aliesha González-Arenas; Marco Antonio Balandrán-Ruiz; María Luisa Mendoza-Magaña; Oscar González-Flores; Ignacio Camacho-Arroyo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-21
Journal Detail:
Title:  Neuroscience letters     Volume:  484     ISSN:  1872-7972     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-09-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  197-200     Citation Subset:  IM    
Copyright Information:
2010 Elsevier Ireland Ltd. All rights reserved.
Centro de Investigación en Reproducción Animal, Universidad Autónoma de Tlaxcala-CINVESTAV, Mexico.
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