Document Detail

Changes in connexin43, the gap junction protein of astrocytes, during development of the rat pineal gland.
MedLine Citation:
PMID:  8391576     Owner:  NLM     Status:  MEDLINE    
The abundance of gap junctions between rat pineal astrocytes formed by connexin43 (Cx43) was studied during development. Levels and distribution of Cx43 were measured by immunoblotting and indirect immunofluorescence, respectively. The amount of Cx43 in cells located within the gland was low until about the 7th postnatal day and increased to adult values between the 14th and 21st days postpartum. Although astrocytes, recognized by their vimentin immunoreactivity, were scarce before birth, they were abundant by the 7th postnatal day suggesting that the low levels of Cx43 found at this age corresponded to a low expression of this protein. Localization of the immunoreactivity to Cx43 and vimentin showed a close correlation, indicating that mature or immature pineal astrocytes form gap junctions made of Cx43. Since Cx43 levels attained their adult values at about the time the innervation and the functional state of the gland reached maturity (2-3 weeks after birth), it is proposed that astrocyte gap junctions are involved in the function of the adult rat pineal gland.
V M Berthoud; J C Sáez
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of pineal research     Volume:  14     ISSN:  0742-3098     ISO Abbreviation:  J. Pineal Res.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-08-03     Completed Date:  1993-08-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8504412     Medline TA:  J Pineal Res     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  67-72     Citation Subset:  IM    
Department of Neuroscience, Albert Einstein College of Medicine Bronx, NY 10461.
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MeSH Terms
Astrocytes / metabolism*
Cell Communication
Fluorescent Antibody Technique
Intercellular Junctions / metabolism
Membrane Proteins / metabolism*
Pineal Gland / growth & development*,  innervation
Rats, Sprague-Dawley
Vimentin / metabolism
Grant Support
Reg. No./Substance:
0/Connexins; 0/Membrane Proteins; 0/Vimentin

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