Document Detail

Changes in the connective tissue composition of the submucosal layer of colonic anastomosis. An immunohistologic study in rats.
MedLine Citation:
PMID:  2596249     Owner:  NLM     Status:  MEDLINE    
Submucosal healing of colonic anastomosis was studied in rats. The unprepared sigmoid colon was divided and colo-colostomy performed, using a one-layer inverting technique. Frozen sections were studied immunohistologically with specific antibodies to fibronectin, laminin and collagen types I, III, IV and V. From the first to the fifth postoperative day the submucosa was highly oedematous. A clear fibronectin reaction was observed in the submucosa, reaching maximum on postoperative day 5. From day 3 onwards the fluorescence intensities of types I and III collagen in the young granulation tissue and of types IV and V collagen and laminin in the regenerating capillaries rapidly increased, with maximum on day 7. The striking changes in the submucosa indicate that the healing process involves not only the actual area of the anastomosis, but also widely the submucosal layer of the adjacent intestine.
P Brasken; M Lehto; S Renvall
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta chirurgica Scandinavica     Volume:  155     ISSN:  0001-5482     ISO Abbreviation:  Acta Chir Scand     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1990-01-23     Completed Date:  1990-01-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7906530     Medline TA:  Acta Chir Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  413-9     Citation Subset:  IM    
Department of Surgery, University of Turku, Finland.
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MeSH Terms
Anastomosis, Surgical*
Collagen / physiology*
Colon / surgery*
Intestinal Mucosa / cytology,  physiology*
Microscopy, Fluorescence
Rats, Inbred Strains
Wound Healing
Reg. No./Substance:

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