Document Detail

Changes in conjugated linoleic acid and palmitoleic acid are correlated to retinol levels in chronic renal failure in both hemodialysis and conservative treatment patients.
MedLine Citation:
PMID:  15854218     Owner:  NLM     Status:  MEDLINE    
An increase in conjugated linoleic acid (CLA), a natural fatty acid present in our diet, which possesses anticarcinogenic and antiatherogenic activities in experimental models, has been found in both the plasma and adipose tissue of end-stage chronic renal failure (ESCRF) patients. Increased levels of retinol have also been found in those patients, due to a reduced excretion of the retinol-binding protein. Since retinol is known to influence lipid metabolism, we evaluated whether changes in retinol, CLA, and other fatty acids are correlated in the plasma of CRF patients. We measured CLA, retinol, and unsaturated fatty acids in the plasma of the following groups: (A) 35 ESCRF patients; (B) 20 hemodialysis (HD) patients; (C) 20 healthy controls. Subjects with total cholesterol and/or triglycerides higher than 250 mg/dL were excluded. We found a significant increase in CLA, retinol, palmitoleic (16:1), and oleic (18:1) acids in ESCRF patients. In HD patients we found a similar pattern, however, CLA increase was not significant. No changes were observed in the other fatty acids measured. In the groups of ESCRF and HD patients, a positive correlation between the levels of plasma retinol and CLA, and between retinol and 16:1 was found. These correlations were not detected in controls. The abnormal levels of plasma retinol in CRF patients might partly explain the changes in CLA and 16:1. The influence of retinol levels on these fatty acids might be due to an induction of delta 9 desaturase. In fact, 16:1 is known to be produced, partly, by delta 9 desaturation of palmitic acid. Moreover, the formation of CLA from delta 9 desaturation of vaccenic acid-a trans-monounsaturated fatty acid present in our diet-has recently been demonstrated in humans. Nevertheless, our data do not represent direct evidence supporting an increased delta 9 desaturase activity in CRF patients. Another possible explanation might be a variation in the exogenous intake.
Leonardo Lucchi; Sebastiano Banni; Anna Iannone; Maria Paola Melis; Gianfranca Carta; Elisabetta Murru; Lina Cordeddu; Lucia Stipo; Simona Uggeri; Valentina Gatti; Vittoria Malaguti; Alberto Albertazzi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Artificial organs     Volume:  29     ISSN:  0160-564X     ISO Abbreviation:  Artif Organs     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-27     Completed Date:  2006-01-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  413-8     Citation Subset:  IM    
Department of Internal Medicine, Division of Nephrology, Dialysis and Transplantation, University Hospital Modena, Modena, Italy.
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MeSH Terms
Adipose Tissue / metabolism
Albumins / analysis
Cholesterol / blood
Cholesterol, HDL / blood
Chromatography, High Pressure Liquid
Fatty Acids, Monounsaturated / blood*,  metabolism
Hemoglobins / analysis
Kidney Failure, Chronic / blood*,  metabolism,  therapy
Linoleic Acid / blood*,  metabolism
Middle Aged
Renal Dialysis*
Triglycerides / blood
Uric Acid / blood
Vitamin A / blood*,  metabolism
Reg. No./Substance:
0/Albumins; 0/Cholesterol, HDL; 0/Fatty Acids, Monounsaturated; 0/Hemoglobins; 0/Triglycerides; 11103-57-4/Vitamin A; 2091-29-4/palmitoleic acid; 2197-37-7/Linoleic Acid; 57-88-5/Cholesterol; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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