Document Detail


Changes in the concentrations of ethanol, methanol and metabolites of serotonin in two successive urinary voids from drinking drivers.
MedLine Citation:
PMID:  9717263     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The urine-ethanol concentration (UEC), the urine-methanol concentration (UMC) and the ratio of serotonin metabolites, 5-hydroxytryptophol (5HTOL) to 5-hydroxyindoleacetic acid (5HIAA), were determined in two successive voids from apprehended drunk drivers (n = 35). The blood-ethanol concentration (BEC) ranged from 0-3.00 g/l (mean 1.87 g/l, median 2.03 g/l) compared with 0-3.96 g/l (mean 2.48 g/l, median 2.73 g/l) in the first urinary void and 0-3.56 g/l (mean 2.24 g/l, median 2.47 g/l) in the second void. The UEC decreased significantly from 2.48 +/- 0.99 g/l to 2.24 +/- 0.95 g/l (mean +/- S.D.) between first and second voids as did the UEC/BEC ratios, changing from 1.33 +/- 0.15 to 1.20 +/- 0.10. The BEC and UEC were highly correlated; r = 0.97 +/- 0.04 (p < 0.001) for the first void and r = 0.98 +/- 0.03 (p < 0.001) for the second void. The UMC increased from 7.51 +/- 4.95 mg/l to 8.01 +/- 5.04 mg/l between the first and second voids and the mean difference of 0.50 +/- 0.78 mg/l was statistically highly significant (p < 0.001). The ratios of 5HTOL/5HIAA were 771 +/- 363 pmol/nmol and 728 +/- 377 pmol/nmol in first and second voids, respectively and the difference was not statistically significant (p > 0.05). Finding raised concentrations of methanol and a high 5HTOL/5HIAA ratio in urine specimens provides additional evidence to confirm recent drinking. These biochemical markers might prove useful whenever the integrity of blood or urine specimens is questioned, for example, owing to contamination with extraneous ethanol during collection or microbial synthesis of ethanol in vitro after sampling.
Authors:
A W Jones; A Helander
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Forensic science international     Volume:  93     ISSN:  0379-0738     ISO Abbreviation:  Forensic Sci. Int.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-09-24     Completed Date:  1998-09-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902034     Medline TA:  Forensic Sci Int     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  127-34     Citation Subset:  IM    
Affiliation:
Department of Forensic Toxicology, University Hospital, Linköping, Sweden. wayne.jones@rk.rmv.se
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MeSH Terms
Descriptor/Qualifier:
Alcoholic Intoxication / urine*
Automobile Driving*
Ethanol / urine*
Humans
Hydroxyindoleacetic Acid / urine*
Hydroxytryptophol / urine*
Methanol / urine*
Serotonin / analogs & derivatives,  urine
Chemical
Reg. No./Substance:
154-02-9/Hydroxytryptophol; 50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid; 64-17-5/Ethanol; 67-56-1/Methanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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