Document Detail


Changes in the concentration of monocytic chemotaxic protein-1 in patients with unstable angina treated with arixtra.
MedLine Citation:
PMID:  22235409     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The time course of inflammatory reaction markers in the blood of patients with unstable angina was studied during therapy including arixtra. Plasma concentration of monocytic chemotaxic protein-1 (MCP-1) decreased on days 2 and 3 in patients receiving arixtra and a trend to an increase in MCP-1 concentration was observed on day 7 after the drug was discontinued. After 1 month, MCP-1 level decreased in all patients. The concentration of highly sensitive C-reactive protein also decreased 1 month after the disease onset; no changes in the concentrations of IL-8 and IL-2 receptor α-subunit were detected during these periods. It seems that arixtra is characterized by an anti-inflammatory effect manifesting by reduction of plasma chemokine MCP-1 concentration.
Authors:
A V Potekhina; T I Arefieva; T L Krasnikova; S I Provatorov; V P Masenko; M K Osyaeva; E A Noeva
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  150     ISSN:  1573-8221     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2012-01-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng; rus     Pagination:  656-8     Citation Subset:  IM    
Affiliation:
Russian Research and Practical Centre of Cardiology, Moscow, Russia. potehina@gmail.com.
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