| Changes in cognition during the course of eight years in elderly Japanese Americans: a multistate transition model. | |
| | |
MedLine Citation:
|
PMID: 20470976 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To analyze cognitive changes in relation to mortality with the use of a multistate transition model. METHODS: In a prospective cohort study of Japanese Americans living in King County, WA, study (n = 1985) cognitive states were defined as the errors in the Cognitive Abilities Screening Instrument score. Transition probabilities were modeled by the use of a modified Poisson distribution with the Poisson mean and mortality dependent on the cognitive state and covariates. RESULTS: During an 8-year follow-up, 21.5% died (95% confidence interval [95% CI], 19.3-23.7), 26.6% experienced cognitive decline (95% CI, 24.2-29.1), and 51.9% remained stable or improved cognitively (95% CI, 49.2-54.6). In multivariable analyses, improvements were notably more likely to occur among younger, more-educated people and in women. Older age, male sex, and less education were each significantly related to mortality. CONCLUSIONS: A multistate transition model can be used to estimate the impact of covariates on the individual probabilities of cognitive improvement, stability, decline, and death. This approach can have advantages for considering how interventions might work on patterns of cognitive change over time, especially if factors associated with the prevention of decline are also associated with risk of death. |
| | |
Authors:
|
Arnold Mitnitski; Nader Fallah; Yougui Wu; Kenneth Rockwood; Amy R Borenstein |
Related Documents
:
|
11295996 - Cerebrovascular and brain morphologic correlates of mild cognitive impairment in the na... 11274306 - Risk of dementia in parkinson's disease: a community-based, prospective study. 16202186 - Risperidone treatment in elderly patients with dementia: relative risk of cerebrovascul... 16222166 - Binge drinking in midlife and dementia risk. 3232686 - B cell neoplasms and occupational asbestos exposure. 20873286 - Racial/ethnic differences in the association between obesity and major depressive disor... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Annals of epidemiology Volume: 20 ISSN: 1873-2585 ISO Abbreviation: Ann Epidemiol Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-05-17 Completed Date: 2010-08-24 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9100013 Medline TA: Ann Epidemiol Country: United States |
Other Details:
|
Languages: eng Pagination: 480-6 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Medicine, Dalhousie University, Halifax, NS, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aging* Asian Americans / statistics & numerical data* Cognition* Cognition Disorders / diagnosis*, epidemiology Female Humans Likelihood Functions Male Models, Psychological Multivariate Analysis Poisson Distribution Prospective Studies Psychological Tests Risk Factors Statistics, Nonparametric Time Factors United States / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
|
MOP-64169//Canadian Institutes of Health Research; R01 AG09769/AG/NIA NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Physical activity and 5-year cognitive decline in the Doetinchem cohort study.
Next Document: Early life and adult socioeconomic influences on mortality risk: preliminary report of a 'pauper ric...