Document Detail

Changes in coenzyme A and carnitine concentrations in superovulated rats.
MedLine Citation:
PMID:  6696924     Owner:  NLM     Status:  MEDLINE    
Changes in the concentrations of total coenzyme A, acetyl CoA, free carnitine and acetylcarnitine were measured in ovaries from immature rats before and after superovulation with 50 I.U. pregnant mare's serum gonadotropin. In addition, the concentrations of total CoA and total acid-soluble carnitine were measured in liver, adrenal glands and skeletal muscle from the same rats. Ovarian concentrations of total CoA, free carnitine and acetylcarnitine increased 3-fold on gonadotropin stimulation, whereas there was no marked change in total CoA and acid-soluble carnitine concentrations in the other organs. In ovary, the ratio of free CoA to acetyl CoA was about 2:1 during the growth period of follicular development and during active steroidogenesis in the luteal phase, but less than 1 when replication stopped and ovulation occurred. These results show that during periods of high energy demand the ovary has a good capacity to accommodate fatty acid oxidation, and supports the evidence that fatty acids are the major source of reducing equivalents for steroidogenesis at these times.
N D Costa; P M Stevenson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  792     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1984 Feb 
Date Detail:
Created Date:  1984-04-04     Completed Date:  1984-04-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  130-4     Citation Subset:  IM    
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MeSH Terms
Acetyl Coenzyme A / metabolism
Acetylcarnitine / metabolism
Carnitine / metabolism*
Coenzyme A / metabolism*
Gonadotropins, Equine / pharmacology
Liver / metabolism*
Ovary / drug effects,  metabolism*
Reg. No./Substance:
0/Gonadotropins, Equine; 14992-62-2/Acetylcarnitine; 541-15-1/Carnitine; 72-89-9/Acetyl Coenzyme A; 85-61-0/Coenzyme A

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