| Changes in coenzyme A and carnitine concentrations in superovulated rats. | |
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MedLine Citation:
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PMID: 6696924 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Changes in the concentrations of total coenzyme A, acetyl CoA, free carnitine and acetylcarnitine were measured in ovaries from immature rats before and after superovulation with 50 I.U. pregnant mare's serum gonadotropin. In addition, the concentrations of total CoA and total acid-soluble carnitine were measured in liver, adrenal glands and skeletal muscle from the same rats. Ovarian concentrations of total CoA, free carnitine and acetylcarnitine increased 3-fold on gonadotropin stimulation, whereas there was no marked change in total CoA and acid-soluble carnitine concentrations in the other organs. In ovary, the ratio of free CoA to acetyl CoA was about 2:1 during the growth period of follicular development and during active steroidogenesis in the luteal phase, but less than 1 when replication stopped and ovulation occurred. These results show that during periods of high energy demand the ovary has a good capacity to accommodate fatty acid oxidation, and supports the evidence that fatty acids are the major source of reducing equivalents for steroidogenesis at these times. |
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Authors:
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N D Costa; P M Stevenson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 792 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 1984 Feb |
Date Detail:
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Created Date: 1984-04-04 Completed Date: 1984-04-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 130-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetyl Coenzyme A
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metabolism Acetylcarnitine / metabolism Animals Carnitine / metabolism* Coenzyme A / metabolism* Female Gonadotropins, Equine / pharmacology Kinetics Liver / metabolism* Ovary / drug effects, metabolism* Ovulation* Rats Superovulation* |
| Chemical | |
Reg. No./Substance:
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0/Gonadotropins, Equine; 14992-62-2/Acetylcarnitine; 541-15-1/Carnitine; 72-89-9/Acetyl Coenzyme A; 85-61-0/Coenzyme A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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