Document Detail

Changes in coagulative and fibrinolytic activities in patients with intracranial hemorrhage.
MedLine Citation:
PMID:  16671428     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate whether any changes occur in the coagulative/fibrinolytic cascade in patients with subarachnoid hemorrhage (SAH) or hypertensive intracerebral hemorrhage (HICH). DESIGN AND METHODS: Subjects included 143 patients with intracranial hemorrhage (SAH, n = 50; HICH, n = 82; ROSC-SAH [return of spontaneous circulation after cardiopulmonary arrest due to SAH], n = 11). Coagulative and fibrinolytic factors were measured in blood samples taken on admission. RESULTS: The prothrombin fragment 1+2 level was significantly higher (p < 0.005) in SAH patients than in HICH patients. The fibrinolytic factors (plasmin alpha 2-plasmin inhibitor complex, D-dimer, or fibrinogen degradation products) in SAH and ROSC-SAH were both significantly higher than those in HICH, but the significance of difference was stronger in the case of ROSC-SAH (p < 0.05). DISCUSSION: Both coagulative and fibrinolytic activities were altered after the onset of SAH. These results demonstrate that the coagulative/fibrinolytic cascade might be activated via different mechanisms in different types of stroke. It remains unclear, however, whether a significant alteration of the fibrinolytic cascade in patients with ROSC-SAH might be a nonspecific phenomenon attributable to the reperfusion after collapse.
T Ebihara; K Kinoshita; A Utagawa; A Sakurai; M Furukawa; Y Kitahata; Y Tominaga; N Chiba; T Moriya; K Nagao; K Tanjoh
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Acta neurochirurgica. Supplement     Volume:  96     ISSN:  0065-1419     ISO Abbreviation:  Acta Neurochir. Suppl.     Publication Date:  2006  
Date Detail:
Created Date:  2006-05-04     Completed Date:  2006-06-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100962752     Medline TA:  Acta Neurochir Suppl     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  69-73     Citation Subset:  IM    
Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, Tokyo, Japan.
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MeSH Terms
Blood Coagulation
Blood Coagulation Disorders / blood*,  diagnosis*,  etiology
Intracranial Hemorrhages / blood*,  complications,  diagnosis*
Middle Aged
Subarachnoid Hemorrhage / blood*,  complications,  diagnosis*

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