| Changes in clinical and physiologic variables predict survival in idiopathic pulmonary fibrosis. | |
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MedLine Citation:
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PMID: 12773325 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is significant heterogeneity in survival time among patients with idiopathic pulmonary fibrosis. Studies of baseline clinical and physiologic variables as predictors of survival time have reported inconsistent results. We evaluated the predictive value of changes in clinical and physiologic variables over time for survival time in 81 patients with biopsy-proven idiopathic pulmonary fibrosis. Six-month changes in dyspnea score, total lung capacity, thoracic gas volume, FVC, FEV1, diffusing capacity of carbon monoxide, partial pressure of arterial oxygen, oxygen saturation, and alveolar-arterial oxygen gradient were predictive of survival time even after adjustment for baseline values. Analyses were repeated on 51 patients with 12-month change data. Twelve-month changes in dyspnea score, total lung capacity, FVC, partial pressure of arterial oxygen, oxygen saturation, and alveolar-arterial oxygen gradient were predictive of survival time after adjustment for baseline values. Evaluation of changes in clinical and physiological variables over 6 and 12 months may provide clinicians with more accurate prognostic information than baseline values alone. |
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Authors:
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Harold R Collard; Talmadge E King; Becki Bucher Bartelson; Jason S Vourlekis; Marvin I Schwarz; Kevin K Brown |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, U.S. Gov't, P.H.S. Date: 2003-05-28 |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: 168 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-08-27 Completed Date: 2003-12-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 538-42 Citation Subset: AIM; IM |
Affiliation:
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Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Health Sciences Center, 1400 Jackson Street, Room F107, Denver, CO 80206, USA. brownk@njc.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cohort Studies Female Humans Longitudinal Studies Male Middle Aged Predictive Value of Tests Prognosis Prospective Studies Pulmonary Fibrosis / mortality*, pathology, physiopathology* Reproducibility of Results Respiratory Function Tests* Severity of Illness Index Survival Rate* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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HL 6767/HL/NHLBI NIH HHS |
| Comments/Corrections | |
Comment In:
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Am J Respir Crit Care Med. 2004 May 1;169(9):1075-6; author reply 1076
[PMID:
15107309
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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