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Changes in circulating red cell volume during the first 6 weeks of life in very low birth weight infants.
MedLine Citation:
PMID:  24135784     Owner:  NLM     Status:  Publisher    
Background:Little is known about the change in circulating red cell volume (RCV) of very low birth weight (VLBW) infants during the first weeks of life.Methods:RCV was measured during the first 5 days in 35 VLBW infants using chromium-51 labeling of the infants' red blood cells (RBCs). RCV was measured again at 6 weeks of age in 12 infants, and the volumes of RBCs lost by phlebotomy and gained by transfusion were recorded between the RCV measurements. In 6 infants, the volume of waste blood on materials contaminated with blood during phlebotomy and usually discarded was measured by radioactive counting.Results:The mean RCV in the first several days of life was 39.6 ml (35.7 ml/kg, range 20.1-58.7 ml/kg). Of the 12 infants whose RCV was measured twice, all but one had a decrease in absolute RCV. The mean RCV initially and at 6 weeks were 37.3 ml and 26.6 ml, respectively. The mean volume of RBCs lost through phlebotomy was 29.2 ml, and the mean volume of RBCs given by transfusion was 34.5 ml.Conclusion:During the first 6 weeks of life, when the anemia of prematurity is evolving, the RCV falls despite complete replacement of RBCs lost by diagnostic phlebotomy with transfused RBCs.Pediatric Research (2013); doi:10.1038/pr.2013.183.
Edward F Bell; Claude Nahmias; John C Sinclair; Alvin Zipursky
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-17
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Pediatrics, University of Iowa, Iowa City, Iowa.
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