Document Detail

Changes in circulating levels and ratios of angiopoietins during pregnancy but not during the menstrual cycle and controlled ovarian stimulation.
MedLine Citation:
PMID:  19476937     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether angiopoietin (ANGPT)-1 and -2 are detectable in the circulation of nonhuman primates and women and whether these levels fluctuate in association with ovarian activity.
DESIGN: Prospective.
SETTING: National Primate Research Center, medical center, and infertility clinic.
PATIENT(S): Adult female rhesus monkeys; 15 women donating oocytes for infertility treatment.
INTERVENTION(S): Controlled ovarian stimulation with gonadotropins, removal of the corpus luteum and ovaries, oocyte retrieval, and ET.
MAIN OUTCOME MEASURE(S): Circulating levels of ANGPT-1 and ANGPT-2.
RESULT(S): Serum ANGPT-1 and ANGPT-2 levels were detectable and invariant in maintaining an ANGPT-1 to -2 ratio >1 in [1] macaques over the course of the natural menstrual cycle, during a controlled ovulation protocol, and after removal of the corpus luteum or ovaries and [2] women undergoing controlled ovarian simulation. In contrast, the ANGPT-1 to -2 ratio was markedly decreased (<<1) at mid-to-late gestation in macaques and in the follicular fluid of women undergoing controlled ovarian simulation because of increased levels of ANGPT-2.
CONCLUSION(S): The ovary and its dominant structures are not major contributors to circulating levels of ANGPT-1 or ANGPT-2. The physiologic importance of the rising levels of ANGPT-2 after the luteal-placental shift in pregnancy is unknown.
Amanda K Hurliman; Leon Speroff; Richard L Stouffer; Phillip E Patton; Annette Lee; Theodore A Molskness
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-05-23
Journal Detail:
Title:  Fertility and sterility     Volume:  93     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-15     Completed Date:  2010-04-02     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1493-9     Citation Subset:  IM    
Copyright Information:
Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Angiopoietin-1 / blood*
Angiopoietin-2 / blood*
Follicular Fluid / metabolism
Gestational Age
Macaca mulatta
Menstrual Cycle / blood*
Ovulation Induction*
Prospective Studies
Time Factors
Grant Support
P51 RR000163/RR/NCRR NIH HHS; P51 RR000163-496026/RR/NCRR NIH HHS; RR00163/RR/NCRR NIH HHS; U54 HD 018185/HD/NICHD NIH HHS; U54 HD018185/HD/NICHD NIH HHS; U54 HD018185-250004/HD/NICHD NIH HHS; U54 HD018185-259001/HD/NICHD NIH HHS
Reg. No./Substance:
0/ANGPT1 protein, human; 0/Angiopoietin-1; 0/Angiopoietin-2

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