| Changes in circulating levels of an anti-inflammatory cytokine interleukin 10 in burned patients. | |
| | |
MedLine Citation:
|
PMID: 10812267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In order to understand the role of an anti-inflammatory cytokine interleukin 10 (IL-10) in the pathophysiology of burn injury, IL-10 levels in serial serum samples of 22 burned patients were analyzed. The total body surface areas (TBSA) of the burn injury ranged from 30 to 90%. Among these 22 patients, 14 recovered and the other eight, who were septic, expired. A significant difference in serum IL-10 values on admission (5-20 h postburn) was found (P<0.05) between patients who survived or died from burn injury as analyzed by the Student's t test. In addition, a significant difference in serum IL-10 on admission was also found (P<0.05) between patients with TBSA of greater or less than 50%. An initial peak serum IL-10 response was detected within 2.5 days postburn. Significant differences in the peak serum IL-10 levels were not found between patients with TBSA of greater or less than 50% and patients who survived or expired from burn injury. Afterwards, serum IL-10 remained low in the survivors, while an increase in serum IL-10 could be detected in the non-survivors with proven sepsis. Levels of circulating IL-6 in these non-surviving patients showed a tendency to increase starting from about 1-2 weeks postburn which coincided temporally with the detection of infections. However, marked increases in circulating IL-10 levels were observed just before death in four of the eight non-survivors. The serum samples of these four patients were collected at 31 h (404.8 pg/ml), 2 h (773.9 pg/ml), 5 days (150.7 pg/ml) and 12 h (177.1 pg/ml) before the expiration of these patients, respectively. IL-10 levels of 28.6, 27. 5 and 13.5 pg/ml were detected in sera of three of the remaining four non-survivors that were collected at 2.5 h, 36 h and 30 h before the expiration of these patients, respectively. There was one non-surviving patient who suffered an 80% burn (patient D4 in Table 1 and Fig. 4) and his IL-10 level at 20 days postburn was 13.4 pg/ml. The serum sample of this patient was collected 22 days before death and he was not suffering from sepsis at this stage. In conclusion, an initial increase in serum levels of IL-10 was detected postburn. A marked increase in serum levels of IL-10 was detected in four of the eight septic patients just before their death. It was considered that a lack and/or a delay in the increase of circulating IL-10 may play a significant role in the pathophysiology of sepsis in burned patients. |
| | |
Authors:
|
F L Yeh; W L Lin; H D Shen |
Related Documents
:
|
3193147 - Diffusion hypoxia: a reappraisal using pulse oximetry. 17184647 - Is extracorporeal life support contraindicated in elderly patients? 3429487 - Gasoline explosions, gasoline sniffing: an epidemic in young adolescents. 3813197 - Acute upper airway injury in burn patients. serial changes of flow-volume curves and na... 19604507 - Occult pneumomediastinum in blunt chest trauma: clinical significance. 1555277 - Electrophysiological findings and long-term follow-up of patients with the permanent fo... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Burns : journal of the International Society for Burn Injuries Volume: 26 ISSN: 0305-4179 ISO Abbreviation: Burns Publication Date: 2000 Aug |
Date Detail:
|
Created Date: 2000-07-11 Completed Date: 2000-07-11 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8913178 Medline TA: Burns Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 454-9 Citation Subset: IM |
Affiliation:
|
Department of Surgery, Veterans General Hospital-Taipei, Shih-pai, Taipei, Taiwan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Body Surface Area Burns / blood*, classification, physiopathology Enzyme-Linked Immunosorbent Assay Female Follow-Up Studies Humans Interleukin-10 / blood*, physiology Interleukin-6 / blood, physiology Interleukin-8 / blood Male Middle Aged Patient Admission Sepsis / blood, physiopathology Statistics as Topic Survival Rate Tumor Necrosis Factor-alpha / analysis |
| Chemical | |
Reg. No./Substance:
|
0/Interleukin-6; 0/Interleukin-8; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Plasma levels of atrial natriuretic peptide in severe burn injury.
Next Document: A prospective study of suicidal burns admitted to the Harare burns unit.