Document Detail


Changes in circulating alphafetoprotein and human chorionic gonadotrophin following chorionic villus sampling.
MedLine Citation:
PMID:  2454849     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chorionic villus sampling (CVS) is rapidly becoming established as a routine procedure for first-trimester fetal diagnosis. The technique can result in fetomaternal haemorrhage and this might sensitize Rhesus-negative mothers and on occasion lead to spontaneous abortion. Serial sampling indicates that there is a rapid rise in alphafetoprotein (AFP) levels following CVS; however, this is not reflected by raised levels at 16-18 weeks and does not influence the subsequent pregnancy outcome. Unlike AFP, alterations in hCG levels are small and variable. Anti-D prophylaxis for non-sensitized Rhesus negative mothers should be given after CVS and the procedure may be contra-indicated in patients who are already sensitized.
Authors:
P D Knott; B Chan; R H Ward; T Chard; J G Grudzinskas; M Petrou; B Modell
Related Documents :
7971759 - Prenatal diagnosis of sjögren-larsson syndrome using enzymatic methods.
17234369 - Early detection of cell-free fetal dna in maternal plasma.
2160999 - The role of transvaginal sonography in chorionic villi sampling.
16084089 - Prenatal diagnosis in laminin alpha2 chain (merosin)-deficient congenital muscular dyst...
23700849 - Somatic and non-somatic problems connected with psoriasis in pregnancy.
23615429 - The effect of interleukin 1β and interleukin 6 on estradiol-17β secretion in the endome...
16223529 - Growth restriction and the cerebral metabolic response to acute hypoxia of chick embryo...
19945699 - Risk of heart failure relapse in subsequent pregnancy among peripartum cardiomyopathy m...
14634579 - Polymorphism in intron 2 of the fetal interleukin-1 receptor antagonist genotype influe...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  27     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-07-29     Completed Date:  1988-07-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  277-81     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, School of Medicine, University College, London, U.K.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Chorionic Gonadotropin / blood*
Chorionic Villi / analysis*
Female
Humans
Pregnancy
Prenatal Diagnosis*
Radioimmunoassay
alpha-Fetoproteins / analysis*
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/alpha-Fetoproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Reduced trypsin-binding capacity of alpha 2-macroglobulin in the peritoneal fluid of women with endo...
Next Document:  Changes in heat shock protein synthesis and hsp70 gene transcription during erythropoiesis of Xenopu...