Document Detail

Changes in cerebral perfusion in extremely LBW infants during the first 72 h after birth.
MedLine Citation:
PMID:  20657347     Owner:  NLM     Status:  MEDLINE    
Cerebral perfusion and its relation with systemic circulation in extremely LBW (ELBW) infants in the early neonatal period are not well understood. The cerebral tissue oxygenation index (TOI) and cerebral fractional tissue oxygen extraction (FTOE) were monitored in stable 16 ELBW infants (GA <29 wk) using near-infrared spectroscopy (NIRS) at 3-6, 12, 18, 24, 36, 48, and 72 h after birth. The left ventricular end-systolic wall stress (ESWS), left ventricular ejection fraction (LVEF), left ventricular cardiac output (LVCO), and superior vena cava (SVC) flow were also measured simultaneously using echocardiography. The ESWS increased till 18 h and then decreased; LVEF, LVCO, and SVC flow decreased till 12 h and increased thereafter. The TOI decreased till 12 h and correlated with SVC flow; FTOE increased until 12 h and then decreased. These changes in variables of NIRS and echocardiographic measurements contrasted to changes in mean arterial blood pressure (MABP), which showed trends of continuous and gradual increase after birth. We conclude that even stable ELBW infants undergo evident transitional changes in cerebral oxygenation and perfusion in the early postnatal period, which may reflect changes in cardiac function and cardiac output.
Takeshi Takami; Daisuke Sunohara; Atsushi Kondo; Norio Mizukaki; Yuusuke Suganami; Yukito Takei; Tasuku Miyajima; Akinori Hoshika
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric research     Volume:  68     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-13     Completed Date:  2011-02-01     Revised Date:  2013-03-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  435-9     Citation Subset:  IM    
Department of Pediatrics, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
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MeSH Terms
Cerebrovascular Circulation / physiology*
Gestational Age
Infant, Extremely Low Birth Weight / physiology*
Infant, Newborn
Oxygen / blood
Oxygen Consumption / physiology
Regional Blood Flow / physiology*
Spectroscopy, Near-Infrared / methods
Reg. No./Substance:

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