| Changes in central arterial pressure waveforms during the normal menstrual cycle. | |
| | |
MedLine Citation:
|
PMID: 17134615 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Changes in estradiol and progesterone during the human menstrual cycle may impact vascular and cardiac function. Renin-angiotensin-aldosterone system (RAAS) hormones increase during the luteal phase of the menstrual cycle and may antagonize the vascular effects of estradiol. This study was designed to investigate central arterial changes, cardiac function, and RAAS activity in response to gonadal steroid variations during the menstrual cycle. METHODS: We studied 15 women during the follicular and midluteal phases with determination of estradiol, progesterone, hormones of the RAAS, and spot urine sodium and creatinine levels. Central pulsatile hemodynamics was evaluated using calibrated carotid tonometry and central aortic Doppler flow. Systolic ejection period (SEP) and systolic pressure time integral (SPTI) were computed from carotid pressure waveforms. RESULTS: Levels of estradiol, progesterone, and RAAS hormones were higher in the luteal phase. SEP and SPTI were lower during the luteal phase, whereas central and peripheral blood pressures and measures of arterial stiffness were unchanged between the two phases. The urine sodium-to-creatinine ratio was similar at both phases. CONCLUSION: Central arterial stiffness does not differ between the follicular and midluteal phases of the menstrual cycle in healthy women, despite significant changes in estradiol and progesterone levels. Systole was shortened during the midluteal phase. RAAS activation during the luteal phase may be responsible for a lack of the expected estradiol-mediated reduction in arterial stiffness between the two phases of the menstrual cycle. Because load was unchanged, the decrease in SEP and SPTI may represent a direct effect of estrogen, progesterone, or RAAS activation on ventricular function. |
| | |
Authors:
|
Nadia Ounis-Skali; Gary F Mitchell; Caren G Solomon; Scott D Solomon; Ellen W Seely |
Related Documents
:
|
12213905 - Variation at the aldosterone synthase (cyp11b2) locus contributes to hypertension in su... 7960015 - Chronic administration of aldosterone depresses baroreceptor reflex function in the dog. 7309905 - Effects of chronic prazosin treatment on the renin-angiotensin-aldosterone system in man. 3067845 - Glucocorticoid excess syndromes causing hypertension. 17331015 - Evaluation of a combined transcutaneous carbon dioxide pressure and pulse oximetry sens... 17477335 - The chemical imagination at work in very tight places. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Journal of investigative medicine : the official publication of the American Federation for Clinical Research Volume: 54 ISSN: 1081-5589 ISO Abbreviation: J. Investig. Med. Publication Date: 2006 Sep |
Date Detail:
|
Created Date: 2006-11-30 Completed Date: 2007-01-16 Revised Date: 2007-12-03 |
Medline Journal Info:
|
Nlm Unique ID: 9501229 Medline TA: J Investig Med Country: Canada |
Other Details:
|
Languages: eng Pagination: 321-6 Citation Subset: IM |
Affiliation:
|
Endocrinology, Diabetes and Hypertension Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Blood Pressure / physiology* Blood Pressure Determination Carotid Arteries / physiology* Female Follicular Phase / physiology* Heart Function Tests Humans Luteal Phase / physiology* Renin-Angiotensin System / physiology |
| Grant Support | |
ID/Acronym/Agency:
|
K24 RR 018613/RR/NCRR NIH HHS; M01 RR 02635/RR/NCRR NIH HHS; R01 HL 67332/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Phase I and Phase II enzyme polymorphisms and childhood cancer.
Next Document: Reengineering clinical research with informatics.