| Changes in cell-mediated immune response after lung resection surgery for MDR-TB patients. | |
| | |
MedLine Citation:
|
PMID: 21514229 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The immune responses of multidrug-resistant tuberculosis (MDR-TB) patients undergoing lung resection surgery were investigated in order to understand the mechanism of strong immune suppression in MDR-TB. We examined changes in cell-mediated immune response (CMI) of a total of sixteen MDR-TB patients, three of them extensively drug-resistant tuberculosis (XDR-TB) patients, after the removal of the heavily diseased lung section. The IFN-γ response to Mycobacterium tuberculosis culture filtrate proteins (Mtb-CFP), one of the most important CMI to defend TB, showed a statistically significant elevation in 2-4 months after operation when compared to the preoperative CMI in patients who were converted into AFB negative and cured in two years' follow-up, suggesting that the recovery of CMI may be one of the key factors in the successful treatment of MDR-TB. Interestingly, IL-10 response to Mtb-CFP was also elevated in 2-4 months after surgery in cured patients although both proliferative response and PBMC composition were not significantly changed. Infection with first- or second-line drugs resistant Mtb reduces the efficiency of chemotherapeutic treatment of MDR-TB to about 50%. Thus, this study suggests that chemotherapeutic treatment of MDR-TB may be more effective when combined with accompanying therapy that increases CMI, includes lung resection surgery. |
| | |
Authors:
|
Seung-Kyu Park; Sunghee Hong; Seok-Yong Eum; In Hee Lee; Donk Ok Shin; Jang Eun Cho; Sungae Cho; Sang-Nae Cho |
Related Documents
:
|
10234189 - Zoite migration during infection: parasite adaptation to host defences. 12778559 - The evolution of immune defense and song complexity in birds. 11878129 - Atopy and helminths. 12858279 - A model for the coevolution of immunity and immune evasion in vector-borne diseases wit... 18999939 - Acute or chronic? within-host models with immune dynamics, infection outcome, and paras... 19223159 - Lines of mice with chronically elevated baseline corticosterone levels are more suscept... 22566899 - Targeting dendritic cells in vivo for cancer therapy. 12654289 - Wnt signaling components in the chicken intestinal tract. 18059979 - Inflammation and spinal cord injury: infiltrating leukocytes as determinants of injury ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-20 |
Journal Detail:
|
Title: Tuberculosis (Edinburgh, Scotland) Volume: - ISSN: 1873-281X ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-4-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100971555 Medline TA: Tuberculosis (Edinb) Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
|
National Masan Tuberculosis Hospital, 486 Gapo-dong, Masan 631-710, Republic of Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Zinc concentrations in serum and follicular fluid during ovarian stimulation and expression of Zn(2+...
Next Document: Molecular epidemiology of tuberculosis in India: Moving forward with a systems biology approach.