Document Detail

Changes in cardiovascular adrenoceptor response in rats subsequent to myocardial infarction.
MedLine Citation:
PMID:  3663025     Owner:  NLM     Status:  MEDLINE    
Since sympatho-adrenal activity was greatest on the second day after experimental myocardial infarction in the rat, we investigated the responsiveness of cardiovascular adrenoceptors in pithed rats at this time and also determined the number of beta-adrenoceptors in the myocardium of the rats. In addition, the sympathetic outflow was measured, as a presynaptic parameter for estimating sympathetic nervous activity. The number of beta-adrenoceptor binding sites and the frequency responses of the heart were unchanged by myocardial infarction on the second day. There was also no difference from control animals with respect to sympathetic outflow. However, the rise in diastolic blood pressure, caused by electrical stimulation of the sympathetic nervous system, was far more pronounced in animals with infarction than in controls. In contrast, rats with myocardial infarction exhibited an attenuated response of diastolic blood pressure to infused noradrenaline. The observed effects can possibly be explained by changes of alpha-adrenoceptors, or perhaps by an enhanced degradation of catecholamines in the endothelium.
D Türck; P Dominiak
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Basic research in cardiology     Volume:  82 Suppl 2     ISSN:  0300-8428     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:  1987  
Date Detail:
Created Date:  1987-11-19     Completed Date:  1987-11-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  317-23     Citation Subset:  IM    
Physiologisches Institut, Universität München.
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MeSH Terms
Blood Pressure / drug effects
Cardiovascular System / physiopathology*
Decerebrate State
Electric Stimulation
Epinephrine / blood,  pharmacology
Fenoterol / pharmacology
Heart Rate / drug effects
Myocardial Infarction / physiopathology*
Norepinephrine / blood
Receptors, Adrenergic / physiology*
Tubocurarine / pharmacology
Vagus Nerve / physiopathology
Reg. No./Substance:
0/Receptors, Adrenergic; 13392-18-2/Fenoterol; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 57-95-4/Tubocurarine

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