| Changes in cardiac pumping efficiency and intra-thoracic organ volume during negative pressure wound therapy of sternotomy wounds, assessment using magnetic resonance imaging. | |
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MedLine Citation:
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PMID: 20633058 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Knowledge on the effects of negative pressure wound therapy (NPWT) on the intra-thoracic organs is limited. The present study was performed to investigate the effects of NPWT on the volume of the intra-thoracic organs, using magnetic resonance imaging (MRI), in a porcine sternotomy wound model. Six pigs underwent median sternotomy followed by NPWT at -75, -125 and -175 mmHg. Six pigs were not sternotomised. MR images covering the thorax and heart were acquired. The volumes of the thoracic cavity, lungs, wound fluid and heart were then determined. The volumes of the thoracic cavity and intra-thoracic organs increased after sternotomy and decreased upon NPWT application. The total heart volume variation, which is inversely related to cardiac pumping efficiency, was higher after sternotomy and decreased during NPWT. NPWT did not result in the evacuation of wound fluid from the bottom of the wound. NPWT largely closes and restores the thoracic cavity. Cardiac pumping efficiency returns to pre-sternotomy levels during NPWT. This may contribute to the clinical benefits of NPWT over open-chest care, including the stabilizing effects and the reduced need for mechanical ventilation. |
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Authors:
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Christian Torbrand; Martin Ugander; Henrik Engblom; Göran K Olivecrona; Olof Gålne; Håkan Arheden; Richard Ingemansson; Malin Malmsjö |
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Publication Detail:
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Type: Corrected and Republished Article; Journal Article |
Journal Detail:
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Title: International wound journal Volume: 7 ISSN: 1742-481X ISO Abbreviation: Int Wound J Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101230907 Medline TA: Int Wound J Country: England |
Other Details:
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Languages: eng Pagination: 305-11 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Lund University Hospital, Lund, Sweden. |
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Corrected and Republished From:
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Int Wound J. 2010 Apr;7(2):115-21
[PMID:
20529152
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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