Document Detail


Changes in the bronchial epithelia in patients with immotile cilia syndromes.
MedLine Citation:
PMID:  14655124     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Immotile cilia syndromes is a cause of recurrent infection of the airways and recurrent bronchopneumonias. Among the ciliary abnormalities are found changes in the structure of the microtubules, unco-ordinated ciliary movements caused by the absence of inner or outer or both dynein arms, and abnormalities of the kinetosomes and/or rete ridges. In patients with ciliary dyskinaesia bronchitis occurs early in life (during infancy) and usually has a recurrent tendency, so that bronchial biopsy is frequently undergone for diagnostic purposes. In this study we include 127 bronchial biopsies from patients (from 2 months to 49 years) unsuccessfully treated for recurrent respiratory tract infections. When performing regular diagnostic procedures on the light and electron microscopic level, we have looked for cilia abnormalities and also focused on changes within the mucosa and submucosa. The most common abnormality recorded was absence of the inner dynein arms, but in 40 cases neither of the dynein arms were present. Only a few patients had classical Kartagener's syndrome. Special attention is drawn to biopsies from elderly patients, in whom long-standing infections were followed by extensive damage to the bronchial epithelium, including even a total absence of ciliated cells. In some cases enhanced regenerative processes and some foci of squamous metaplasia were found. In two cases even foci of low-grade dysplasia were diagnosed.
Authors:
Wiesława Biczysko; Andrzej Marszałek; Monika Seget; Anna Breborowicz; Joanna Goździk; Grazyna Sierakowska-Urbańska
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Folia morphologica     Volume:  62     ISSN:  0015-5659     ISO Abbreviation:  Folia Morphol. (Warsz)     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-12-05     Completed Date:  2004-01-14     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0374620     Medline TA:  Folia Morphol (Warsz)     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  393-5     Citation Subset:  IM    
Affiliation:
Department of Clinical Pathomorphology, University of Medical Sciences, Poznań, Poland.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Bronchi / pathology*
Child
Child, Preschool
Cilia / ultrastructure*
Ciliary Motility Disorders / pathology*
Dyneins / ultrastructure
Female
Humans
Infant
Male
Microvilli / ultrastructure
Middle Aged
Respiratory Mucosa / ultrastructure*
Chemical
Reg. No./Substance:
EC 3.6.4.2/Dyneins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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