Document Detail


Changes in brain volume after EC-IC bypass surgery.
MedLine Citation:
PMID:  18496949     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied changes in brain volume on magnetic resonance imaging in 10 patients with and without EC-IC bypass surgery who met the inclusion criteria for the Japanese EC-IC bypass trial, a multicenter, randomized, double-blind, prospective study of patients with hemodynamic brain ischemia due to cerebral artery occlusive disease. We also examined the association of cerebral hemodynamics on single photon emission computed tomography with the changes in brain volume. As a result, the affected/unaffected ratio of the % brain volume declined in patients without EC-IC bypass surgery (p < 0.02, n = 4), and the affected/unaffected % rCBF ratio increased in patients with the surgery (p < 0.03, n = 6). Acetazolamide reactivity increased in the affected hemisphere of patients with surgery (p < 0.01). And also two-year increase (decrease) in acetazolamide reactivity of the affected hemisphere showed a significant positive correlation with 2-year changes in the affected/unaffected % brain volume ratio (R2 = 0.737, p = 0.0007). Change in acetazolamide reactivity might be a good predictor for brain atrophy in cerebral artery occlusive disease.
Authors:
T Inoue; J Jinnouchi
Related Documents :
17522989 - The impact of prophylactic treatment on post-traumatic epilepsy after severe traumatic ...
9210989 - Psychomotor agitation following gabapentin use in brain injury.
9171929 - Heart-rate variability in chronic traumatic brain injury.
21036949 - White matter abnormalities in methcathinone abusers with an extrapyramidal syndrome.
9712009 - Axonal damage correlates with disability in patients with relapsing-remitting multiple ...
2064489 - The evaluation of patients with human immunodeficiency virus-related disorders and brai...
20579909 - Effect of chronic vagal nerve stimulation on interictal epileptiform discharges.
22358239 - Visual acuity and retinal function in patients with bardet-biedl syndrome.
17522989 - The impact of prophylactic treatment on post-traumatic epilepsy after severe traumatic ...
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta neurochirurgica. Supplement     Volume:  103     ISSN:  0065-1419     ISO Abbreviation:  Acta Neurochir. Suppl.     Publication Date:  2008  
Date Detail:
Created Date:  2008-05-23     Completed Date:  2008-07-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100962752     Medline TA:  Acta Neurochir Suppl     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  79-82     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Cerebrovascular Center and Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan. itkkr@qmed.hosp.go.jp
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Brain / physiopathology*
Case-Control Studies
Cerebral Arterial Diseases / pathology*,  therapy*
Cerebral Revascularization / methods*
Cerebrovascular Circulation / drug effects,  physiology*
Double-Blind Method
Female
Humans
Longitudinal Studies
Male
Middle Aged
Prospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cerebral revascularization by EC-IC bypass--present status.
Next Document:  Less invasive technique for EC-IC bypass.