Document Detail

Changes in brain volume after EC-IC bypass surgery.
MedLine Citation:
PMID:  18496949     Owner:  NLM     Status:  MEDLINE    
We studied changes in brain volume on magnetic resonance imaging in 10 patients with and without EC-IC bypass surgery who met the inclusion criteria for the Japanese EC-IC bypass trial, a multicenter, randomized, double-blind, prospective study of patients with hemodynamic brain ischemia due to cerebral artery occlusive disease. We also examined the association of cerebral hemodynamics on single photon emission computed tomography with the changes in brain volume. As a result, the affected/unaffected ratio of the % brain volume declined in patients without EC-IC bypass surgery (p < 0.02, n = 4), and the affected/unaffected % rCBF ratio increased in patients with the surgery (p < 0.03, n = 6). Acetazolamide reactivity increased in the affected hemisphere of patients with surgery (p < 0.01). And also two-year increase (decrease) in acetazolamide reactivity of the affected hemisphere showed a significant positive correlation with 2-year changes in the affected/unaffected % brain volume ratio (R2 = 0.737, p = 0.0007). Change in acetazolamide reactivity might be a good predictor for brain atrophy in cerebral artery occlusive disease.
T Inoue; J Jinnouchi
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta neurochirurgica. Supplement     Volume:  103     ISSN:  0065-1419     ISO Abbreviation:  Acta Neurochir. Suppl.     Publication Date:  2008  
Date Detail:
Created Date:  2008-05-23     Completed Date:  2008-07-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100962752     Medline TA:  Acta Neurochir Suppl     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  79-82     Citation Subset:  IM    
Department of Neurosurgery, Cerebrovascular Center and Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
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MeSH Terms
Brain / physiopathology*
Case-Control Studies
Cerebral Arterial Diseases / pathology*,  therapy*
Cerebral Revascularization / methods*
Cerebrovascular Circulation / drug effects,  physiology*
Double-Blind Method
Longitudinal Studies
Middle Aged
Prospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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