Document Detail

Changes in brain mitochondrial bioenergetics in protein-deficient rats.
MedLine Citation:
PMID:  2513864     Owner:  NLM     Status:  MEDLINE    
An assessment of mitochondrial bioenergetics in protein-malnourished rats indicates that there is a reduction of brain mitochondrial metabolism in protein malnutrition. Specifically, mitochondria of protein-malnourished offspring of malnourished rats exhibit (i) an enhancement of state 4 respiration, (ii) a reduction of ADP-stimulated state 3 respiration, (iii) a decrease in ADP:O ratios, (iv) reductions of FCCP-induced ATPase action and in the rates of proton and calcium ion translocation, and (v) diminished activities of redox enzymes. In general, these changes are less pronounced in malnourished weanling rats born of healthy dams. Although the exact molecular mechanism of these defects is not yet known, the alterations are definitely caused by diet-induced changes in the structure and integrity of inner mitochondrial membrane components.
O O Olorunsogo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of experimental pathology     Volume:  70     ISSN:  0007-1021     ISO Abbreviation:  Br J Exp Pathol     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-02-16     Completed Date:  1990-02-16     Revised Date:  2012-05-07    
Medline Journal Info:
Nlm Unique ID:  0372543     Medline TA:  Br J Exp Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  607-19     Citation Subset:  IM    
Biochemistry Department, College of Medicine, University of Ibadan, Nigeria.
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MeSH Terms
Adenosine Diphosphate / physiology
Brain / embryology,  enzymology,  metabolism*
Energy Metabolism / physiology
Maternal-Fetal Exchange / physiology
Mitochondria / enzymology,  metabolism*
Oxygen Consumption
Protein-Energy Malnutrition / metabolism*
Rats, Inbred Strains
Reg. No./Substance:
58-64-0/Adenosine Diphosphate

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