| Changes in brain intracellular pH and membrane phospholipids on oxygen therapy in hypoxic patients with chronic obstructive pulmonary disease. | |
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MedLine Citation:
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PMID: 12603086 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic hypoxia due to chronic obstructive pulmonary disease (COPD) constitutes a stress to cerebral metabolic homeostasis. Previous studies using phosphorus-31 magnetic resonance spectroscopy (31P MRS) have suggested that the brains of such patients utilize anaerobic glycolysis, which in neonatal, animal, and in vitro studies is associated with a protective intracellular alkalosis. To identify such a compensatory intracellular alkalosis in hypoxic COPD patients, in vivo cerebral 31P MRS was performed in eight patients and eight controls. The mean intracellular pH (pHi) in patients with COPD was similar to that of age-matched controls, but decreased in the patients with COPD by a mean pHi of 0.02 (p = 0.04), following supplemental oxygen. There was no change in cerebral pHi in normal subjects following oxygen administration. The broadband component of the MR spectrum increased in all the patients with COPD (p = 0.01), suggesting altered phospholipid membrane fluidity in the brain associated with the change in pHi following oxygen administration. The change in the broadband resonance was strongly correlated with the change in pHi (r = -0.68, p = 0.014). This study suggests that patients with COPD exhibit a compensatory change in pHi and abnormalities in cerebral membrane phospholipid conformation in the face of chronic hypoxia. |
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Authors:
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G Hamilton; R Mathur; J M Allsop; D M Forton; N S Dhanjal; R J Shaw; S D Taylor-Robinson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Metabolic brain disease Volume: 18 ISSN: 0885-7490 ISO Abbreviation: Metab Brain Dis Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-02-26 Completed Date: 2003-05-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8610370 Medline TA: Metab Brain Dis Country: United States |
Other Details:
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Languages: eng Pagination: 95-109 Citation Subset: IM |
Affiliation:
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The Robert Steiner Magnetic Resonance Imaging Unit, MRC Clinical Sciences Centre, Faculty of Medicine, Hammersmith Hospital Campus, Imperial College, London, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anoxia / drug therapy*, etiology, metabolism* Brain / metabolism* Chronic Disease Control Groups Female Gases / blood Humans Hydrogen / metabolism* Hydrogen-Ion Concentration Intracellular Membranes / metabolism Magnetic Resonance Spectroscopy Male Membranes / metabolism Middle Aged Oxygen / therapeutic use* Phospholipids / metabolism* Pulmonary Disease, Chronic Obstructive / complications* |
| Chemical | |
Reg. No./Substance:
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0/Gases; 0/Phospholipids; 1333-74-0/Hydrogen; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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