Document Detail


Changes in body fat measured by DEXA in patients taking different formulations of stavudine.
MedLine Citation:
PMID:  16452067     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Lipoatrophy is a frequent complication of chronic stavudine therapy. Stavudine extended release formulation (stavudine ER) gives lower peak and higher trough levels than the immediate release formulation (stavudine IR), and we hypothesized that the lower peak might result in less lipoatrophy. OBJECTIVE: To compare the rate of peripheral lipoatrophy between patients taking stavudine ER and stavudine IR. METHOD: Body composition was measured by dual energy X-ray absorptiometry (DEXA) every 6 months for 18 months in 29 patients taking either stavudine ER or IR as part of a randomized controlled clinical trial. RESULTS: DEXA fat measurements did not differ between the ER and IR groups at baseline, after a median of 32 months on stavudine-containing treatment. Over the 18 months of follow-up in the whole cohort limb fat decreased by a mean of 0.29 +/- 0.50 kg (p = .01) and leg fat percent decreased by a mean of 1.23% +/- 1.92% (p = .001), whereas trunk fat and trunk-to-limb fat percent ratio did not change significantly. There was no significant difference between the ER and IR groups in the rate of change of any of the fat parameters. At study completion, the proportion of patients with clinical lipodystrophy was similar in the stavudine ER and stavudine IR groups (67% and 64%, respectively; p = .893). CONCLUSION: Stavudine ER does not appear to cause less peripheral lipoatrophy.
Authors:
Yong Yang; Annelies Wilder-Smith; Anushia Panchalingam; Naing Oo Tha; Nicholas I Paton
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  HIV clinical trials     Volume:  6     ISSN:  1528-4336     ISO Abbreviation:  HIV Clin Trials     Publication Date:    2005 Nov-Dec
Date Detail:
Created Date:  2006-02-02     Completed Date:  2006-05-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100936377     Medline TA:  HIV Clin Trials     Country:  United States    
Other Details:
Languages:  eng     Pagination:  337-43     Citation Subset:  IM    
Affiliation:
Infectious Disease Research Centre, Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore.
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MeSH Terms
Descriptor/Qualifier:
Absorptiometry, Photon
Adult
Body Composition / drug effects
Cohort Studies
Delayed-Action Preparations
Female
HIV Infections / drug therapy*,  pathology
HIV-1 / growth & development*
HIV-Associated Lipodystrophy Syndrome / chemically induced*,  pathology,  prevention & control
Humans
Male
Reverse Transcriptase Inhibitors / administration & dosage*,  adverse effects*
Stavudine / administration & dosage*,  adverse effects*
Chemical
Reg. No./Substance:
0/Delayed-Action Preparations; 0/Reverse Transcriptase Inhibitors; 3056-17-5/Stavudine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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