Document Detail

Changes in body fat mass in male hemodialysis patients: a comparison between diabetics and nondiabetics.
MedLine Citation:
PMID:  11576957     Owner:  NLM     Status:  MEDLINE    
Nutritional status is an important factor that affects morbidity and mortality of hemodialysis patients. We investigated 1-year changes in body fat mass of male patients undergoing hemodialysis (duration, 4.9 +/- 2.5 years). Fat mass of 217 male patients (age 60 +/- 13 years) was measured by dual x-ray absorptiometry twice in a 1-year interval. The patients consisted of 70 with diabetes mellitus and 147 without diabetes. At the second measurement compared with the first, a significant decrease in fat mass was observed in diabetic patients (12.1 +/- 4.4 kg versus 11.0 +/- 4.7 kg; P < 0.01); there were no significant changes in fat mass in nondiabetic patients (12.2 +/- 5.0 kg versus 11.9 +/- 4.9 kg; P = 0.15). Significant differences in percent fat mass changes per year were seen between diabetic and nondiabetic patients (P < 0.05). Protein catabolic rates of diabetic patients were significantly lower than those of nondiabetic patients (0.86 +/- 0.18 g/kg/d versus 0.93 +/- 0.19 g/kg/d; P < 0.05). In all patients, there was a significant correlation between protein catabolic rates and percent fat mass changes per year (r = 0.15; P < 0.05). These results showed that body fat mass was decreased significantly in 1 year in male diabetic patients with maintenance hemodialysis, suggesting poorer nutritional status in these patients. Poor protein intake may be one of the risk factors for the decrease in fat mass. Dual x-ray absorptiometry assessment of fat mass changes is suggested as a useful method to examine clinically the nutritional status of hemodialysis patients.
S Okuno; E Ishimura; M Kim; T Izumotani; T Otoshi; K Maekawa; T Yamakawa; H Morii; M Inaba; Y Nishizawa
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of kidney diseases : the official journal of the National Kidney Foundation     Volume:  38     ISSN:  1523-6838     ISO Abbreviation:  Am. J. Kidney Dis.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-09-28     Completed Date:  2001-12-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8110075     Medline TA:  Am J Kidney Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S208-11     Citation Subset:  IM    
Kidney Center, Shirasagi Hospital, Osaka, Japan.
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MeSH Terms
Absorptiometry, Photon
Adipose Tissue / metabolism*,  radiography
Body Mass Index
Diabetes Mellitus / metabolism*,  therapy*
Dietary Proteins / administration & dosage,  metabolism
Middle Aged
Nutritional Status
Renal Dialysis*
Reg. No./Substance:
0/Dietary Proteins
Erratum In:
Am J Kidney Dis 2002 Jan;39(1):312

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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