| Changes in blood volume and vascular compliance during body heating in rats. | |
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MedLine Citation:
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PMID: 3174391 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of hyperthermia on blood volume and effective vascular compliance were studied in control and heat acclimated rats (three weeks at 32 degrees C and 50% R.H.). Experiments were performed on conscious rats whose abdominal aorta and both jugular veins were cannulated. Continuous changes in blood volume (BV) were monitored by measuring 51Cr tagged erythrocyte dilution, using an arterio-venous extracorporeal shunt passing through a gamma counter. Total vascular compliance was calculated from the relation between changes in BV and central venous pressure during 10 min of infusion of saline at a rate of 1.6% body wt/10 min. Hyperthermia induced a significant blood volume expansion. This expansion was more pronounced in non-acclimated rats. Effective vascular compliance was similar in the normothermic, both non-acclimated and acclimated rats. However, while hyperthermia did not affect the vascular compliance of non-acclimated rats, it was decreased significantly in the acclimated hyperthermic rats. The data suggest that changes in vascular compliance play a role when rapid blood volume changes take place, especially in acclimated hyperthermic animals. The relations between changes in vascular compliance and heat induced redistribution of cardiac output are discussed. |
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Authors:
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M Horowitz; E Sugimoto; T Okuno; T Morimoto |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pflügers Archiv : European journal of physiology Volume: 412 ISSN: 0031-6768 ISO Abbreviation: Pflugers Arch. Publication Date: 1988 Sep |
Date Detail:
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Created Date: 1988-11-22 Completed Date: 1988-11-22 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0154720 Medline TA: Pflugers Arch Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 354-8 Citation Subset: IM |
Affiliation:
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Department of Physiology, Kyoto Prefectural University of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acclimatization Animals Blood Vessels / physiology*, physiopathology Blood Volume* Body Temperature Central Venous Pressure* Fever / physiopathology* Hot Temperature Male Rats |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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