Document Detail

Changes in blood volume and hematocrit during acute preoperative volume loading with 5% albumin or 6% hetastarch solutions in patients before radical hysterectomy.
MedLine Citation:
PMID:  11605923     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The impact of acute preoperative volume loading with colloids on blood volume has not been investigated sufficiently. METHODS: Before surgery, in 20 patients undergoing major gynecologic procedures, volume loading was performed during anesthesia by infusing approximately 20 ml/kg of colloid at a rate of 90 ml/min (group I: 5% albumin solution; group II: 6% hetastarch solution; n = 10 each). Plasma volume (indocyanine green dilution technique), erythrocyte volume (labeling erythrocytes with fluorescein), hematocrit, total protein, and hetastarch plasma concentrations (group II) were measured before and 30 min after the end of infusion. RESULTS: More than 1,350 ml of colloid (approximately 50% of the baseline plasma volume) were infused within 15 min. Thirty minutes after the infusion had been completed, blood volume was only 524 +/- 328 ml (group I) and 603 +/- 314 ml (group II) higher than before volume loading. The large vessel hematocrit (measured by centrifugation) dropped more than the whole body hematocrit, which was derived from double-label measurements of blood volume. CONCLUSIONS: The double-label measurements of blood volume performed showed that 30 min after the infusion of approximately 20 ml/kg of 5% albumin or 6% hetastarch solution (within 15 min), only mean 38 +/- 21% and 43 +/- 26%, respectively, of the volume applied remained in the intravascular space. Different, i.e., earlier or later, measuring points, different infusion volumes, infusion rates, plasma substitutes, or possibly different tracers for plasma volume measurement might lead to different results concerning the kinetics of fluid or colloid extravasation.
M Rehm; M Haller; V Orth; U Kreimeier; M Jacob; H Dressel; S Mayer; H Brechtelsbauer; U Finsterer
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesiology     Volume:  95     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-18     Completed Date:  2001-11-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  849-56     Citation Subset:  AIM; IM    
Klinik für Anästhesiologie, Ludwig-Maximilians-Universität, Klinikum Grosshadern, Munich, Germany.
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MeSH Terms
Albumins / therapeutic use*
Blood Proteins / metabolism
Blood Volume / drug effects*
Coloring Agents
Erythrocyte Volume
Hetastarch / therapeutic use*
Indocyanine Green
Middle Aged
Pharmaceutical Solutions
Plasma Substitutes / therapeutic use*
Preoperative Care
Reg. No./Substance:
0/Albumins; 0/Blood Proteins; 0/Coloring Agents; 0/Pharmaceutical Solutions; 0/Plasma Substitutes; 3599-32-4/Indocyanine Green; 9005-27-0/Hetastarch

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