Document Detail

Changes in blood viscosity and plasma proteins in carcinoma.
MedLine Citation:
PMID:  65499     Owner:  NLM     Status:  MEDLINE    
Blood viscosity and plasma protein concentrations were measured in 31 patients with a variety of visceral carcinomas. The mean whole blood viscosity was not elevated over normal controls because of a significantly lowered mean hematocrit. However, when hematocrit was eliminated as a variable by adjusting the hematocrit to 45%, the mean whole blood viscosity was significantly elevated in the group with carcinoma. Both the plasma viscosity and the tendency for red cell aggregation were significantly elevated. Since blood is a non-Newtonian fluid, and its viscosity increases markedly at low shear rates, these rheological abnormalities would be most important at the low shear rates characteristic of the venous circulation. It is suggested that these abnormalities in blood viscosity and red cell aggregation may be contributing to the high incidence of venous thromboembolism seen in patients with neoplastic.
G W Tietjen; S Chien; P Scholz; F E Gump; J M Kinney
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of surgical oncology     Volume:  9     ISSN:  0022-4790     ISO Abbreviation:  J Surg Oncol     Publication Date:  1977  
Date Detail:
Created Date:  1977-04-28     Completed Date:  1977-04-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0222643     Medline TA:  J Surg Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  53-9     Citation Subset:  IM    
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MeSH Terms
Alpha-Globulins / analysis
Beta-Globulins / analysis
Blood Proteins / analysis*
Blood Viscosity*
Fibrinogen / analysis
Neoplasms / blood*
gamma-Globulins / analysis
Reg. No./Substance:
0/Alpha-Globulins; 0/Beta-Globulins; 0/Blood Proteins; 0/gamma-Globulins; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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