Document Detail

Changes in blood pressure and thermographic values resulting from use of a beta-blocker plus diuretic and of an alpha-beta-blocker plus diuretic.
MedLine Citation:
PMID:  3836858     Owner:  NLM     Status:  MEDLINE    
Changes in arterial blood pressure and in thermographic values were evaluated in two groups of 15 hypertensive patients, each of which was treated, on a random basis, with a combination of atenolol plus chlorthalidone or a combination of labetalol plus chlorthalidone. Both combinations produced a statistically significant reduction in blood pressure values (p less than 0.01) with no changes in heart rate. Telethermographic investigations revealed the presence of hypothermia of the hands before treatment in all the hypertensive patients examined, but not in the control group (10 normal subjects with no vascular and/or hyperthermic disease). After one month of treatment, no changes in peripheral vascularization were observed in the group treated with atenolol plus chlorthalidone, except for 4 cases showing mild improvement, probably due to a reduction in peripheral resistance as a result of the treatment and to a consequent increase in blood flow in the area investigated. In the group treated with labetalol plus chlorthalidone, on the other hand, a substantial recovery of vascular flow was observed in 12 patients as a result of the treatment, while the remaining 3 patients showed a fair degree of improvement (2 degrees C). Both preparations lent themselves to simplified administration regimens with good patient compliance and no adverse reactions.
R De Cesaris; A Grimaldi; M Balestrazzi; G Ranieri; R Chiarappa; F Avantaggiato
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drugs under experimental and clinical research     Volume:  11     ISSN:  0378-6501     ISO Abbreviation:  Drugs Exp Clin Res     Publication Date:  1985  
Date Detail:
Created Date:  1986-09-16     Completed Date:  1986-09-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7802135     Medline TA:  Drugs Exp Clin Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  725-9     Citation Subset:  IM    
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MeSH Terms
Atenolol / therapeutic use*
Body Temperature / drug effects*
Chlorthalidone / therapeutic use*
Drug Therapy, Combination
Heart Rate / drug effects
Hypertension / drug therapy*,  physiopathology
Labetalol / therapeutic use*
Middle Aged
Reg. No./Substance:
29122-68-7/Atenolol; 36894-69-6/Labetalol; 77-36-1/Chlorthalidone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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