Document Detail

Changes in blood pressure and dipsogenic responsiveness to angiotensin II during chronic exposure of rats to cold.
MedLine Citation:
PMID:  1871198     Owner:  NLM     Status:  MEDLINE    
Hypertension accompanies chronic exposure of rats to cold (5-6 degrees C). Systolic, diastolic, and mean blood pressures become elevated, and hypertrophy of the heart occurs. A previous study from this laboratory suggested that the renin-angiotensin system may play a role. The present study was carried out to assess this further. Thus, in addition to measurement of systolic blood pressure at intervals during exposure to cold, plasma renin activity and the dipsogenic responsiveness to acute administration of angiotensin II were also measured to assess the functional status of the renin-angiotensin system. The results showed a significant (p less than 0.05) increase in systolic blood pressure during the third week of exposure to cold. In contrast, plasma renin activity (PRA) increased within the first week of exposure to cold, and declined thereafter to reach the level of the control by the third week of exposure to cold. By the fourth week, PRA decreased to a level significantly (p less than 0.05) below that of the control group. The responsiveness to acute administration of angiotensin II (AII), as assessed by the drinking response, increased significantly (p less than 0.05) by the third week of exposure to cold and remained significantly elevated during the fourth week. There was a significant (p less than 0.01) direct relationship between dipsogenic responsiveness to AII and blood pressure in the cold-treated (r = .57), but not the control group (r = .12). There was also a significant (r = -.91) indirect linear relationship between PRA and dipsogenic responsiveness to AII. Cold-treated rats had significant increases in urinary norepinephrine output and weights of heart, kidneys, adrenals, and brown adipose tissue characteristic of rats acclimated to cold.(ABSTRACT TRUNCATED AT 250 WORDS)
M J Fregly; O Shechtman; P van Bergen; C Reeber; P E Papanek
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  38     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-09-16     Completed Date:  1991-09-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  837-42     Citation Subset:  IM    
Department of Physiology, University of Florida, College of Medicine, Gainesville 32610.
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MeSH Terms
Adaptation, Physiological
Angiotensin II / pharmacology*
Blood Pressure / physiology*
Cold Temperature / adverse effects*
Drinking / drug effects*,  physiology
Hypertension / etiology
Norepinephrine / urine
Rats, Inbred Strains
Renin / blood
Renin-Angiotensin System / drug effects,  physiology
Reg. No./Substance:
11128-99-7/Angiotensin II; 51-41-2/Norepinephrine; EC

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