Document Detail


Changes in blood pressure after administration of hydroxocobalamin: relationship to changes in plasma cobalamins-(III) concentrations in healthy volunteers.
MedLine Citation:
PMID:  18584369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess the relationship between blood pressure changes following infusion of antidotal doses of hydroxocobalamin and plasma concentrations of total and free cobalamins-(III). METHODS: Independent groups of healthy volunteers received single intravenous doses of 2.5, 5, 7.5, or 10 g hydroxocobalamin over 7.5 to 30 minutes. RESULTS: In the pharmacokinetic population (n = 41), hydroxocobalamin caused short-lived mean blood pressure increases. Blood pressure increased shortly after initiation of infusion and returned nearly to baseline by 4 hours post-infusion. The time course of blood pressure changes coincided with that of changes in plasma total and free cobalamins-(III). Change in mean arterial pressure (MAP) was strongly correlated with plasma area-under-the-concentration-time curves (AUCs) of total and free cobalamins-(III) during infusion (r > 0.7) but not through 24 hours post-infusion (r < or = 0.36). CONCLUSION: The short-lived increase in mean blood pressure during administration of antidotal doses of hydroxocobalamin is closely linked to initial exposure to total and free cobalamins-(III).
Authors:
Wolfgang Uhl; Arno Nolting; Dieter Gallemann; Stefan Hecht; Andreas Kovar
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical toxicology (Philadelphia, Pa.)     Volume:  46     ISSN:  1556-9519     ISO Abbreviation:  Clin Toxicol (Phila)     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-27     Completed Date:  2008-07-15     Revised Date:  2009-11-17    
Medline Journal Info:
Nlm Unique ID:  101241654     Medline TA:  Clin Toxicol (Phila)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  551-9; discussion 576-7     Citation Subset:  AIM; IM    
Affiliation:
Merck KGaA, Darmstadt, Germany. wolfgang.uhl@merck.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Antidotes / administration & dosage,  adverse effects*,  pharmacokinetics
Area Under Curve
Blood Pressure / drug effects*
Dose-Response Relationship, Drug
Female
Humans
Hydroxocobalamin / administration & dosage,  adverse effects*,  pharmacokinetics
Infusions, Intravenous
Male
Middle Aged
Poisoning / drug therapy
Time Factors
Vitamin B 12 / blood*
Chemical
Reg. No./Substance:
0/Antidotes; 13422-51-0/Hydroxocobalamin; 68-19-9/Vitamin B 12

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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