| Changes in blood pressure after administration of hydroxocobalamin: relationship to changes in plasma cobalamins-(III) concentrations in healthy volunteers. | |
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MedLine Citation:
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PMID: 18584369 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the relationship between blood pressure changes following infusion of antidotal doses of hydroxocobalamin and plasma concentrations of total and free cobalamins-(III). METHODS: Independent groups of healthy volunteers received single intravenous doses of 2.5, 5, 7.5, or 10 g hydroxocobalamin over 7.5 to 30 minutes. RESULTS: In the pharmacokinetic population (n = 41), hydroxocobalamin caused short-lived mean blood pressure increases. Blood pressure increased shortly after initiation of infusion and returned nearly to baseline by 4 hours post-infusion. The time course of blood pressure changes coincided with that of changes in plasma total and free cobalamins-(III). Change in mean arterial pressure (MAP) was strongly correlated with plasma area-under-the-concentration-time curves (AUCs) of total and free cobalamins-(III) during infusion (r > 0.7) but not through 24 hours post-infusion (r < or = 0.36). CONCLUSION: The short-lived increase in mean blood pressure during administration of antidotal doses of hydroxocobalamin is closely linked to initial exposure to total and free cobalamins-(III). |
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Authors:
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Wolfgang Uhl; Arno Nolting; Dieter Gallemann; Stefan Hecht; Andreas Kovar |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical toxicology (Philadelphia, Pa.) Volume: 46 ISSN: 1556-9519 ISO Abbreviation: Clin Toxicol (Phila) Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-06-27 Completed Date: 2008-07-15 Revised Date: 2009-11-17 |
Medline Journal Info:
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Nlm Unique ID: 101241654 Medline TA: Clin Toxicol (Phila) Country: United States |
Other Details:
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Languages: eng Pagination: 551-9; discussion 576-7 Citation Subset: AIM; IM |
Affiliation:
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Merck KGaA, Darmstadt, Germany. wolfgang.uhl@merck.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antidotes / administration & dosage, adverse effects*, pharmacokinetics Area Under Curve Blood Pressure / drug effects* Dose-Response Relationship, Drug Female Humans Hydroxocobalamin / administration & dosage, adverse effects*, pharmacokinetics Infusions, Intravenous Male Middle Aged Poisoning / drug therapy Time Factors Vitamin B 12 / blood* |
| Chemical | |
Reg. No./Substance:
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0/Antidotes; 13422-51-0/Hydroxocobalamin; 68-19-9/Vitamin B 12 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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