Document Detail

Changes in blood oxidative and antioxidant parameters in a group of chinese patients with age-related macular degeneration.
MedLine Citation:
PMID:  22456773     Owner:  NLM     Status:  In-Data-Review    
Objective: To measure the oxidative and antioxidant biochemical parameters in the serum of Chinese patients with age-related macular degeneration (AMD) and in a similar age control group from the same area. Design: A case-control study. Participants: 56 AMD patients ( 21 early dry, 13 geographic atrophy and 22 wet form) and 34 normal subjects, similar for age and sex were studied. Measurements: Both groups completed a questionnaire about demographic characters and dieatry habit, and the levels of serum lipid peroxidation (malondialdehyde, MDA) and antioxidants parameters (vitamin C and E, the activities of superoxide dismutase-SOD, total antioxidant capacity -TAC ) were determined. Results: There was a significantly higher frequency of daily intake of fruit and legumes in controls than in AMD patients. There was a significantly increased serum MDA levels and SOD activities, and significantly decreased serum vitamin C and total antioxidant capacity in AMD patients as compared to controls. The intensity of lipid peroxidation was higher with the progression of AMD. There was not difference in serum vitamin E levels between AMD patients and controls. Conclusion: Oxido-reduction disturbance may be involved in the pathogenesis of AMD. There is a significantly decreased antioxidant capacity in AMD patients.
X L Shen; J H Jia; P Zhao; R Fan; X Y Pan; H M Yang; L Liu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of nutrition, health & aging     Volume:  16     ISSN:  1760-4788     ISO Abbreviation:  J Nutr Health Aging     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100893366     Medline TA:  J Nutr Health Aging     Country:  France    
Other Details:
Languages:  eng     Pagination:  201-4     Citation Subset:  IM    
X.L. Shen, Department of Neurology, The First Affiliated Hospital, China Medical University, Shenyang 110001, China. Telephone: +86 24 23901209, Fax: +86 24 23269025, E-mail address:
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