| Changes in blood oxidative and antioxidant parameters in a group of chinese patients with age-related macular degeneration. | |
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MedLine Citation:
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PMID: 22456773 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective: To measure the oxidative and antioxidant biochemical parameters in the serum of Chinese patients with age-related macular degeneration (AMD) and in a similar age control group from the same area. Design: A case-control study. Participants: 56 AMD patients ( 21 early dry, 13 geographic atrophy and 22 wet form) and 34 normal subjects, similar for age and sex were studied. Measurements: Both groups completed a questionnaire about demographic characters and dieatry habit, and the levels of serum lipid peroxidation (malondialdehyde, MDA) and antioxidants parameters (vitamin C and E, the activities of superoxide dismutase-SOD, total antioxidant capacity -TAC ) were determined. Results: There was a significantly higher frequency of daily intake of fruit and legumes in controls than in AMD patients. There was a significantly increased serum MDA levels and SOD activities, and significantly decreased serum vitamin C and total antioxidant capacity in AMD patients as compared to controls. The intensity of lipid peroxidation was higher with the progression of AMD. There was not difference in serum vitamin E levels between AMD patients and controls. Conclusion: Oxido-reduction disturbance may be involved in the pathogenesis of AMD. There is a significantly decreased antioxidant capacity in AMD patients. |
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Authors:
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X L Shen; J H Jia; P Zhao; R Fan; X Y Pan; H M Yang; L Liu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The journal of nutrition, health & aging Volume: 16 ISSN: 1760-4788 ISO Abbreviation: J Nutr Health Aging Publication Date: 2012 |
Date Detail:
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Created Date: 2012-03-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100893366 Medline TA: J Nutr Health Aging Country: France |
Other Details:
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Languages: eng Pagination: 201-4 Citation Subset: IM |
Affiliation:
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X.L. Shen, Department of Neurology, The First Affiliated Hospital, China Medical University, Shenyang 110001, China. Telephone: +86 24 23901209, Fax: +86 24 23269025, E-mail address: sxl630101@126.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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