| Changes in blood lipids during six days of overfeeding with medium or long chain triglycerides. | |
| | |
MedLine Citation:
|
PMID: 2187945 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Although medium chain triglyceride (MCT) is less calorically dense than long chain triglyceride (LCT), it produces a greater thermic effect following ingestion. We hypothesized that the previously observed high rate of thermogenesis produced by MCT overfeeding was due to hepatic de novo synthesis of long chain fatty acids (LCFA) from the excess medium chain fatty acids (MCFA). To study this, we compared the effects of overfeeding MCT- and LCT-containing diets on blood lipid profiles. Ten in-patient, nonobese males were overfed (150% of estimated energy requirements) two formula diets for 6 days each, in a randomized crossover design. Diets differed only in the composition of the fat and contained either 40% of energy as MCT or LCT (soybean oil). The major differences between diets in the resulting pattern of blood lipids were: 1) a reduction in fasting serum total cholesterol concentrations with the LCT, but not the MCT diet; and 2) a threefold increase in fasting serum triglyceride concentrations with MCT, but not LCT, diet. Moreover, 10% of the fasting triglyceride fatty acids were medium chain and 40% were 16:0 with the MCT diet. This compared to 1% and 20% for medium chain and 16:0, respectively, with the LCT diet. In addition, there were increases in 16:1, 18:0, and 18:1 in the triglycerides during MCT feeding. The changes in fatty acids in triglycerides with MCT feeding are consistent with the hypothesis that excess dietary MCT cause a significant increase in the hepatic synthesis of these fatty acids from MCFA through de novo synthesis and/or chain elongation and desaturation. These processes could account for the higher rate of postprandial thermogenesis with MCT as compared to LCT. |
| | |
Authors:
|
J O Hill; J C Peters; L L Swift; D Yang; T Sharp; N Abumrad; H L Greene |
Related Documents
:
|
17191405 - Variations in fat and fatty acid intakes of adult males from three regions of india. 1461925 - Sex and dietary fat modulate hepatic prostaglandin f2 alpha in f344/n rats. 7554415 - Recent insights into dietary fats and cardiovascular disease. 8869885 - Effect of dietary n-9 eicosatrienoic acid on the fatty acid composition of plasma lipid... 7759375 - Influence of crambe meal as a protein source on intake, site of digestion, ruminal ferm... 1733565 - Effects of phenobarbital on i-compounds in liver dna as a function of age in male rats ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of lipid research Volume: 31 ISSN: 0022-2275 ISO Abbreviation: J. Lipid Res. Publication Date: 1990 Mar |
Date Detail:
|
Created Date: 1990-06-26 Completed Date: 1990-06-26 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 407-16 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Vanderbilt University, Nashville, TN. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Blood Glucose / metabolism Cholesterol / blood Chromatography, Gas Diet Fasting Fatty Acids / administration & dosage, blood Humans Insulin / blood Lipids / blood* Liver / metabolism Male Triglycerides / administration & dosage*, blood |
| Grant Support | |
ID/Acronym/Agency:
|
DK26652/DK/NIDDK NIH HHS; DK38088/DK/NIDDK NIH HHS; RR00095/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 0/Fatty Acids; 0/Lipids; 0/Triglycerides; 11061-68-0/Insulin; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Tracheal stenosis in infants and young children.
Next Document: The value of body surface potential maps in detecting abnormal ventricular wall motion.