| Changes in blood coagulation, platelet aggregation, and lipid metabolism in rats given lipids containing docosahexaenoic acid. | |
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MedLine Citation:
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PMID: 9339545 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to identify an adequate intake level of docosahexaenoic acid (DHA), changes in various parameters related to health benefits were studied in rats fed on diets containing 10% test lipids at different n-3(DHA)/n-6 ratios for two weeks. An evaluation of the critical level of the dietary n-3/n-6 ratio which had a significant effect on the parameters of several tissues indicated that the response to the dietary ratios differed according to the parameter, the variation in ratio ranging approximately from 0.20 to 1.77 with either a positive or negative effect on the health benefit. These results suggest that a suitable intake level of DHA would be within this range. In view of safety, however, the critical level for the dietary n-3/n-6 ratio may be around 0.56, as shown by a detailed analysis on the lower limit level of the harmful parameters. We thus propose that the dietary intake of DHA should not be more than 0.56 in terms of the n-3/n-6 ratio. |
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Authors:
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N Yamada; Y Kobatake; S Ikegami; T Takita; M Wada; J Shimizu; Y Kanke; S Innami |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Bioscience, biotechnology, and biochemistry Volume: 61 ISSN: 0916-8451 ISO Abbreviation: Biosci. Biotechnol. Biochem. Publication Date: 1997 Sep |
Date Detail:
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Created Date: 1998-02-05 Completed Date: 1998-02-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9205717 Medline TA: Biosci Biotechnol Biochem Country: JAPAN |
Other Details:
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Languages: eng Pagination: 1454-8 Citation Subset: B |
Affiliation:
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Department of Nutrition, Faculty of Agriculture, Tokyo University of Agriculture, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta, Thoracic / drug effects, metabolism Blood Coagulation / drug effects* Diet Docosahexaenoic Acids / pharmacology* Eicosanoids / biosynthesis Fatty Acids / metabolism Lipid Metabolism* Lipid Peroxides / metabolism Male Phospholipids / metabolism Platelet Aggregation / drug effects* Platelet Count Rats Rats, Sprague-Dawley Vitamin E / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Eicosanoids; 0/Fatty Acids; 0/Lipid Peroxides; 0/Phospholipids; 1406-18-4/Vitamin E; 25167-62-8/Docosahexaenoic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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