Document Detail

Changes in blood chemistry, hematology, and histology caused by a selenium/vitamin E deficiency and recovery in chicks.
MedLine Citation:
PMID:  9630419     Owner:  NLM     Status:  MEDLINE    
Exudative diathesis, a condition caused by a selenium (Se)/vitamin E deficiency, was studied in chicks. Trios of chicks that showed clinical signs of exudative diathesis were matched for severity. One was injected subcutaneously with 0.5 mL distilled water, and the other two received 15 microg of Se in 0.5 mL distilled water. A chick fed a diet with supplemental Se also received 0.5 mL distilled water. Blood was collected from three chicks 2 d after injection, and from the other chick, 6 d after injection. After blood was collected, pectoral muscle and bone marrow were collected. Deficient chicks showed varying degrees of necrosis in pectoral muscle, whereas recovering chicks had extensive fibrosis in pectoral muscle. An analysis of blood showed differences in CO2, glucose, Se, glutathione peroxidase, alanine aminotransferase, aspartate aminotransferase, and creatine kinase. Heterophils and monocytes were increased in deficient chicks; lymphocytes, basophils, and hemoglobin decreased. After 6 d of recovery, all of the changes noted above were correcting toward normal. Eosinophils, in contrast, were unaffected by a deficiency, but increased in recovering chicks. It is hypothesized that cytokines associated with the inflammatory response accentuate the clinical signs of exudative diathesis.
A Bartholomew; D Latshaw; D E Swayne
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Biological trace element research     Volume:  62     ISSN:  0163-4984     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:    1998 Apr-May
Date Detail:
Created Date:  1998-08-05     Completed Date:  1998-08-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  7-16     Citation Subset:  IM    
Department of Animal Sciences, Ohio State University, Columbus 43210, USA.
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MeSH Terms
Bone Marrow / pathology
Clinical Chemistry Tests
Deficiency Diseases / blood*,  pathology
Femur / pathology*
Leukocyte Count
Selenium / deficiency*
Vitamin E Deficiency / blood*,  pathology
Reg. No./Substance:

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