Document Detail


Changes in bioavailability and tissue distribution of selenium caused by magnesium deficiency in rats.
MedLine Citation:
PMID:  9100219     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We investigated the effect of dietary magnesium (Mg) deficiency on the bioavailability and tissue distribution of selenium (Se). METHODS: Wistar rats were fed an Mg-deficient diet for 70 days (D). Selenium content in plasma, whole blood, skeletal muscle, heart, kidney and femoral bone was determined after 7, 35, 49 and 70 days on a Mg-deficient diet. RESULTS: The Mg-deficient diet significantly decreased Se absorption from week 7 until the end of the experimental period; this effect was accompanied by a significant decrease in Se balance. We found a direct linear correlation between Se absorption and retention (balance) (pair-fed controls r = 0.842, p < 0.001; Mg-deficient rats r = 0.959, p < 0.001), and between Se absorbed and plasma Se concentration (controls r = 0.527, p < 0.02; Mg-deficient rats r = 0.704, p < 0.001). In general there were no significant correlations between urinary Se and any other parameter. Tissue analyses showed that after 7 days, Mg deficiency reduced erythrocyte Se and significantly increased plasma and kidney Se. Heart Se was significantly increased only at the end of the study. We found no significant changes in skeletal muscle or bone Se at any time during the experimental period. CONCLUSION: Chronic Mg deficiency decreases Se absorption and retention and erythrocyte concentrations of this mineral, and increases Se in plasma, kidney and heart. Under our experimental conditions, absorption appears to play an important role in the regulation of the tissue distribution of Se.
Authors:
A Jiménez; E Planells; P Aranda; M Sánchez-Viñas; J Llopis
Related Documents :
1813319 - Hepatoprotective effect of selenium and vitamin e in rabbits fed a high-fat diet.
15844809 - Effect of age on utilization of selenium by chickens.
3572559 - Influence of dietary vitamin e on nutritional pancreatic atrophy in selenium-deficient ...
14704309 - Prebiotic inulin enriched with oligofructose in combination with the probiotics lactoba...
8332589 - Effect of turmeric on xenobiotic metabolising enzymes.
3355109 - Dietary thiocyanate and n-nitrosation in vivo in the wistar rat.
2073909 - Review of clinical trials: proving the lipid hypothesis.
8914949 - Docosahexaenoic acid-rich fish oil does not affect serum lipid concentrations of normol...
15257389 - Does exaggerated morphology preclude plasticity to cuckoldry in the midshipman fish ( p...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American College of Nutrition     Volume:  16     ISSN:  0731-5724     ISO Abbreviation:  J Am Coll Nutr     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-06-06     Completed Date:  1997-06-06     Revised Date:  2008-06-23    
Medline Journal Info:
Nlm Unique ID:  8215879     Medline TA:  J Am Coll Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  175-80     Citation Subset:  IM    
Affiliation:
Institute of Nutrition and Food Technology, University of Granada, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Biological Availability
Diet
Magnesium Deficiency / metabolism*
Male
Rats
Rats, Wistar
Selenium / blood,  pharmacokinetics*,  urine
Tissue Distribution
Chemical
Reg. No./Substance:
7782-49-2/Selenium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Simvastatin further enhances the hypocholesterolemic effect of soy protein in rabbits.
Next Document:  Whole blood ionized magnesium in the healthy neonate.