| Changes in the atherogenic risk factor profile according to degree of weight loss. | |
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MedLine Citation:
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PMID: 15102630 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The atherogenic risk factor profile in obese subjects is characterised by hypertension, reduced high density lipoprotein (HDL) cholesterol, increased low density lipoprotein (LDL) cholesterol and triglycerides, and insulin resistance. AIMS: To examine the amount of weight reduction required to improve the atherogenic profile. METHODS: Changes of systolic and diastolic blood pressure, HDL and LDL cholesterol, triglycerides, and insulin resistance, based on the HOMA model over a one year period were studied in obese children, who attended the intervention programme "Obeldicks". The children were divided into four groups according to the change in body mass index standard deviation score (SDS-BMI): group I, increase in SDS-BMI; group II, decrease in SDS-BMI <0.25; group III, decrease in SDS-BMI > or =0.25-<0.5; group IV, decrease in SDS-BMI > or =0.5. RESULTS: A total of 130 children (mean age 10.7 years, range 4-15; mean SDS-BMI 2.5, range 2.0-4.0) were studied. The four groups did not differ in age, gender, or degree of overweight (SDS-BMI). An increasing SDS-BMI (group I: n = 20) was followed by a significant increase in insulin resistance (HOMA). Systolic and diastolic blood pressure, LDL cholesterol, triglycerides, and insulin resistance (HOMA) decreased significantly while HDL cholesterol increased significantly in group IV (n = 37). LDL cholesterol also decreased significantly in group III (n = 40); there was no significant change of the other parameters in groups I, II, and III. CONCLUSION: Over a time period of one year increasing weight in obese children leads to an increase in insulin resistance. Weight loss is associated with an improvement in the atherogenic profile and in insulin resistance, but only if the SDS-BMI decreases by at least 0.5 over a one year period. |
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Authors:
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T Reinehr; W Andler |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of disease in childhood Volume: 89 ISSN: 1468-2044 ISO Abbreviation: Arch. Dis. Child. Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-04-22 Completed Date: 2004-05-12 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372434 Medline TA: Arch Dis Child Country: England |
Other Details:
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Languages: eng Pagination: 419-22 Citation Subset: AIM; IM |
Affiliation:
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Department of Vestische Kinderklinik, University of Witten-Herdecke, Datteln, Germany. T.Reinehr@kinderklinik-datteln.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Arteriosclerosis / blood, etiology, prevention & control* Blood Pressure / physiology Body Mass Index Child Child, Preschool Cholesterol, HDL / blood Cholesterol, LDL / blood Female Humans Insulin Resistance Male Obesity / blood, complications, therapy* Risk Factors Triglycerides / blood Weight Loss / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Triglycerides |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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