Document Detail

Changes in arterial plasma potassium and ventilation during exercise in man.
MedLine Citation:
PMID:  2616927     Owner:  NLM     Status:  MEDLINE    
We have investigated the relationship between arterial plasma potassium ( [K+]a) and ventilation (VE) in man because hyperkalaemia has been shown to increase VE in the anaesthetized cat by direct stimulation of the arterial chemoreceptors. Six healthy male volunteers undertook about of sub-maximal (100 W) and maximal (sprint ca. 350 W) exercise on a cycle ergometer. VE was measured breath-by-breath and arterial blood was sampled at regular intervals from a catheter inserted into a brachial artery for measurement of [K+]a and base excess. Changes in [K+]a closely mirrored changes in VE during exercise and recovery. At 100 W [K+]a increased from 4 mM to 5 mM, and during the sprint [K+]a increased to ca. 7 mM. Base excess did not mirror VE in that it reached its nadir 1-3 min after exercise had stopped, when [K+]a and VE were both falling. The increases in [K+]a seen here are probably sufficient to enhance the arterial chemoreceptor drive during exercise. Furthermore, the close temporal relationship between [K+]a and VE suggests that it is possible that exercise hyperkalaemia may contribute to the control of breathing in exercise.
D J Paterson; P A Robbins; J Conway
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration physiology     Volume:  78     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-03-13     Completed Date:  1990-03-13     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  323-30     Citation Subset:  IM    
University Laboratory of Physiology, Oxford, U.K.
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MeSH Terms
Osmolar Concentration
Physical Endurance
Potassium / blood*
Respiration / physiology*
Grant Support
//Wellcome Trust
Reg. No./Substance:

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