| Changes in arterial, mixed venous and intraerythrocytic ion concentrations during prolonged exercise. | |
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MedLine Citation:
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PMID: 21059004 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Reasons for performing study: Prolonged equine exercise can cause hypochloraemic alkalosis and hypokalaemia secondary to the loss of hypertonic sweat. Movement of ions in and out of erythrocytes during exercise may help regulate acid-base balance and changes in plasma ion concentrations. The extent to which this happens during prolonged equine exercise has not been reported. Objectives: To measure changes in blood gases and major plasma and intraerythrocytic (iRBC) ion concentrations of horses undergoing prolonged submaximal exercise. Methods: Six horses were trotted at ∼30% V̇O(2max) on a treadmill for 105 min. Arterial ((a) ) and mixed venous ((v) ) blood samples were collected every 15 min, and pre- and post exercise. Blood gases and plasma (pl) concentrations of sodium, potassium, chloride and protein were measured and their iRBC concentrations calculated and compared (P<0.05). Results: P(a) CO(2) decreased in all horses. pl[Cl(-) ](v) decreased and [HCO(3) (-) ](v) increased. Due to the exhalation of CO(2) and chloride shifting, [HCO(3) (-) ](a) <[HCO(3) (-) ](v,) pl[Cl(-) ](a) >pl[Cl(-) ](v) and iRBC[Cl(-) ](a) <iRBC[Cl(-) ](v) . pl[K(+) ](a) and pl[K(+) ](v) both initially increased then decreased and horses were hypokalaemic post exercise. Both iRBC[Cl(-) ](a) and iRBC[Cl(-) ](v) decreased over the course of exercise but there was no change in the arteriovenous difference between them. There was no arteriovenous difference in pl[K(+) ]. iRBC[K (+) ](a) >iRBC[K(+) ](v) . Conversely, iRBC[Na(+) ](a) <iRBC[Na(+) ](v) . pl[Na(+) ](a) <pl[Na(+) ](v) and [TP](a) <[TP](v) . Conclusions: Significant arteriovenous differences in iRBC and plasma concentrations of chloride, potassium and sodium reflect the role that movement of ions across erythrocyte cell membranes play in regulating acid-base balance and plasma concentrations of these ions. Exhalation of CO(2) has a major influence on this ion flux. |
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Authors:
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N D Meyer; W M Bayly; R H Sides; K J Wardrop; B K Slinker |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Equine veterinary journal Volume: 42 Suppl 38 ISSN: 2042-3306 ISO Abbreviation: Equine Vet. J. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0173320 Medline TA: Equine Vet J Country: England |
Other Details:
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Languages: eng Pagination: 185-90 Citation Subset: IM |
Copyright Information:
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© 2010 EVJ Ltd. |
Affiliation:
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College of Veterinary Medicine, Washington State University, Washington, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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