| Changes in arterial blood pressure after single oral administration of milk-casein-derived peptides in spontaneously hypertensive rats. | |
| | |
MedLine Citation:
|
PMID: 20397194 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
In this study we evaluated the short-term oral antihypertensive effect of several peptide sequences isolated from casein fractions, previously characterized as in vitro angiotensin-converting enzyme-inhibitors, in spontaneously hypertensive rats (SHR). Systolic blood pressure (SBP) and the diastolic blood pressure (DBP) of the rats were measured by the tail cuff method before administration and also 2, 4, 6, 8 and 24 h post-administration. The sequences LVYPFTGPIPN, HLPLP, IAK, YAKPVA and WQVLPNAVPAK showed a clear decrease in SBP and DBP in SHR. HPHPHLSF caused a significant decrease of the DBP in the SHR, but this sequence did not modify the SBP of these animals in a significant manner. KKYNVPQL did not modify SBP in the SHR, and caused a slight, but significant and maintained, decrease in DBP in these animals. SBP and DBP returned to baseline values 24 h post-administration of all peptides. In conclusion, these peptides are bioactive ingredients with potential benefit in the prevention and treatment of hypertension or other associated disorders. |
| | |
Authors:
|
Marta Miguel; José Ángel Gómez-Ruiz; Isidra Recio; Amaya Aleixandre |
Related Documents
:
|
18635974 - Comparison of a radial artery compression device with invasive radial artery blood pres... 12477164 - Reproducibility of ambulatory blood pressure measures in african-american adolescents. 8894054 - How many sphygmomanometric cuff inflations are necessary to obtain a hemodynamic baseline? 12658764 - Assessment of effect of angiotensin ii receptor antagonist losartan on aortic distensib... 12213104 - Sensory-motor responses to volume-controlled duodenal distension. 15050274 - Combined trabeculectomy and vitrectomy for pseudophakic malignant glaucoma and extensiv... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Molecular nutrition & food research Volume: 54 ISSN: 1613-4133 ISO Abbreviation: Mol Nutr Food Res Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-10-08 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101231818 Medline TA: Mol Nutr Food Res Country: Germany |
Other Details:
|
Languages: eng Pagination: 1422-7 Citation Subset: IM |
Affiliation:
|
Departamento de Farmacología, Facultad de Medicina, U. Complutense, Madrid, Spain. marta.miguel@ifi.csic.es |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The (193-209) 17-residues peptide of bovine ?-casein is transported through Caco-2 monolayer.
Next Document: Glucuronidation of zearalenone, zeranol and four metabolites in vitro: formation of glucuronides by ...