Document Detail

Changes in arterial blood pressure after single oral administration of milk-casein-derived peptides in spontaneously hypertensive rats.
MedLine Citation:
PMID:  20397194     Owner:  NLM     Status:  In-Process    
In this study we evaluated the short-term oral antihypertensive effect of several peptide sequences isolated from casein fractions, previously characterized as in vitro angiotensin-converting enzyme-inhibitors, in spontaneously hypertensive rats (SHR). Systolic blood pressure (SBP) and the diastolic blood pressure (DBP) of the rats were measured by the tail cuff method before administration and also 2, 4, 6, 8 and 24 h post-administration. The sequences LVYPFTGPIPN, HLPLP, IAK, YAKPVA and WQVLPNAVPAK showed a clear decrease in SBP and DBP in SHR. HPHPHLSF caused a significant decrease of the DBP in the SHR, but this sequence did not modify the SBP of these animals in a significant manner. KKYNVPQL did not modify SBP in the SHR, and caused a slight, but significant and maintained, decrease in DBP in these animals. SBP and DBP returned to baseline values 24 h post-administration of all peptides. In conclusion, these peptides are bioactive ingredients with potential benefit in the prevention and treatment of hypertension or other associated disorders.
Marta Miguel; José Ángel Gómez-Ruiz; Isidra Recio; Amaya Aleixandre
Related Documents :
18004104 - Validation of the saa-102 home blood pressure monitor according to the protocols of the...
12270984 - Pulse pressure and subclinical cardiovascular damage in primary hypertension.
9760344 - Magnitude and time course of hemodynamic responses to mueller maneuvers in patients wit...
17625394 - Validation of the omron m6 (hem-7001-e) upper-arm blood pressure measuring device accor...
19323864 - Social class-related gradient in the association of skeletal growth with blood pressure...
19865054 - Intraocular pressure measurements with the newly reconfigured ocuton s*tt-mv self-tonom...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular nutrition & food research     Volume:  54     ISSN:  1613-4133     ISO Abbreviation:  Mol Nutr Food Res     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101231818     Medline TA:  Mol Nutr Food Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1422-7     Citation Subset:  IM    
Departamento de Farmacología, Facultad de Medicina, U. Complutense, Madrid, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The (193-209) 17-residues peptide of bovine ?-casein is transported through Caco-2 monolayer.
Next Document:  Glucuronidation of zearalenone, zeranol and four metabolites in vitro: formation of glucuronides by ...