Document Detail

Changes in apolipoproteins during the acute phase of Kawasaki disease.
MedLine Citation:
PMID:  8775549     Owner:  NLM     Status:  MEDLINE    
To determine disturbances of lipid metabolism in patients with Kawasaki disease, we investigated changes in the serum levels of apolipoproteins and serum lipids. Results were as follows. Total serum cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) decreased during the early stage of Kawasaki disease. The apo A-I and A-II levels were low until the 2nd week of illness. Apo B decreased during the 1st week of illness, but rose slightly during the 2nd and 3rd weeks. The apo B/apo A-I ratio and the apo B/TC ratio were high in the early stages of illness. The group of patients with coronary artery lesions showed low levels of TC and HDL-C, and low levels of apo A-I, A-II and B during the early stages, compared with the group without coronary artery lesions. The apo B/TC ratio was significantly higher in the patients with coronary artery lesions during the 2nd week of illness. Our findings suggest an association between changes in serum lipids and apolipoproteins and coronary artery involvement in Kawasaki disease. These abnormalities may indicate the presence of early coronary arteriosclerosis.
H Kim; H Yamaguchi; K Inamo; T Okada; K Harada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta paediatrica Japonica; Overseas edition     Volume:  37     ISSN:  0374-5600     ISO Abbreviation:  Acta Paediatr Jpn     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-12-04     Completed Date:  1996-12-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370357     Medline TA:  Acta Paediatr Jpn     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  672-6     Citation Subset:  IM    
Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan.
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MeSH Terms
Acute Disease
Apolipoproteins / blood*
Apolipoproteins A / blood
Apolipoproteins B / blood
Child, Preschool
Cholesterol, HDL / blood
Coronary Artery Disease / blood,  etiology
Mucocutaneous Lymph Node Syndrome / blood*,  complications
Reg. No./Substance:
0/Apolipoproteins; 0/Apolipoproteins A; 0/Apolipoproteins B; 0/Cholesterol, HDL

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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