| Changes in the amplitude of electrocardiogram QRS complexes during follow-up of heart failure patients. | |
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MedLine Citation:
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PMID: 21376341 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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INTRODUCTION: Changes in the electrocardiogram QRS amplitudes (ECGΔ) during follow-up of heart failure (HF) patients have not been clinically exploited heretofore. METHODS: We examined ECGΔ during follow-up of HF patients by employing 42 triplets of ECGs, other laboratory and HF-related clinical data corresponding to clinical stability, worsening, and recovery from 37 HF patients. RESULTS: The % changes (Δ%) in the summed QRS amplitude of all 12 leads (ΣQRS(12L)), 6 precordial leads (ΣQRS(V1-V6)), 6 limb leads (ΣQRS(6L)), leads I+II (ΣQRS(I + II)), and lead aVR were evaluated. Also relationships between the ECG variables and body weight (BW), percent body-fat, and B-type natriuretic peptide (BNP) were examined. The QRS amplitude(s) in all ECG variables decreased from clinical stability to worsening HF, and returned to baseline at recovery. During HF worsening, Δ% was highest in lead aVR (-15.3 ± 12.3%), followed by Δ% in ΣQRS(6L) (-12.9 ± 10.1%) and ΣQRS(I + II) (-12.1 ± 10.8%). At worsening HF and its recovery, Δ% in ΣQRS(6L) correlated with Δ% in percent body-fat (r = 0.333, P = .031; r = 0.308, P = .047). At recovery, Δ% in each ECG variable correlated with Δ% in BW. Receiver operating characteristic (ROC) analysis showed that ≥16% reduction of ΣQRS(6L) and ΣQRS(I + II) discriminated between stable and worsening HF, with a sensitivity of 43% and 40%, and specificity of 98% for both. ECG variables from limb lead(s) had as good area under the curve (AUC) (0.78-0.84) as BNP (AUC: 0.88) for identifying worsening HF. CONCLUSIONS: Changes of the QRS amplitudes in ECGs are as useful for monitoring HF patients as BNP. |
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Authors:
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Hajime Kataoka; John E Madias |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-2 |
Journal Detail:
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Title: Journal of electrocardiology Volume: - ISSN: 1532-8430 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0153605 Medline TA: J Electrocardiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Internal Medicine, Nishida Hospital, Oita, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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